HLA-DR14

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title: "HLA-DR14" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public tags: ["hla-dr-haplotypes"] topic_path: "general/hla-dr-haplotypes" source: "https://en.wikipedia.org/wiki/HLA-DR14" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0

HLA-DR14(DR14) is a HLA-DR serotype that recognizes the DRB1*1401 to *1408, *1410 to *1418, and other *14 gene products. DR14 serotype is a split antigen of the older HLA-DR6 serotype group which also contains the similar HLA-DR13 antigens.

Alleles

Serotypes are unknown the following alleles: DRB1**1409, *1419 to *1462

Disease associations

DRB1*1402: juvenile rheumatoid arthritis, increased longevity in Okinawans.

Extended linkage

DR*14:DQ5 haplotype: increased risk for non-AChR autoantibodies in myasthenia gravis.

Genetic Linkage

::data[format=table]

DRADRB1DRB3DQA1DQB1DRB1HLA-AHLA-BDRB1
DR14(6)-DR52*0101*1401*0201
*0101*1402*0201
*0101*1403*0101
DR14-DQ5(5.3, 1)*0104*0503*1401
A11-B35-DR14(6)*1101*3501*1401
A2-B51(5)-DR14(6)*0201*5101*1401
::

HLA-DR13 is genetically linked to HLA-DR52 and HLA-DQ5 (HLA-DQ1) serotypes.

References

References

  1. [http://www.ebi.ac.uk/imgt/hla/allele.html derived from IMGT/HLA]
  2. DR1404 - 3%
  3. DR4 - 25%
  4. (2004). "HLA-DRB1 alleles and HLA-DRB1 shared epitopes are markers for juvenile rheumatoid arthritis subgroups in Colombian mestizos.". Hum Immunol.
  5. (2006). "Strong association of MuSK antibody-positive myasthenia gravis and HLA-DR14-DQ5". Neurology.
  6. (2004). "HLA-DRB1 and -DRB3 allele frequencies and haplotypic associations in Koreans". Hum. Immunol..

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hla-dr-haplotypes