HLA-DR12

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title: "HLA-DR12" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public tags: ["hla-dr-haplotypes"] topic_path: "general/hla-dr-haplotypes" source: "https://en.wikipedia.org/wiki/HLA-DR12" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0

HLA-DR12(DR12) is a HLA-DR serotype that recognizes the DRB1*1201 to *1203, *1206. DR12 serotype is a split antigen of the older HLA-DR5 serotype group which also contains the similar HLA-DR11 antigens.

Serology

The table above describes the efficiency of serological typing of DR12 and DR5. Serotypes are unknown the following alleles: DRB1*1204,*1205 to *1207 to *1215

Alleles

There are only 2 common allels for DRB1*12, *1201 and *1202. *1202 is more common on the West Pacific Rim and particularly Indochina and the South Pacific.

Disease associations

DR12 is associated with vulval lichen sclerosus, and undifferentiated spondyloarthritis.

DRB1*1201 is associated with iritis in juvenile arthritis, primary antiphospholipid syndrome, tiopronin intolerance in rheumatoid arthritis, adult chronic articular Still's disease

DRB1*1202 is found to be increased in narcolepsy associated sudden death syndrome in the Thai population, and narcolepsy in the Japanese population.

Extended linkage

DRB112:DQA10505:DQBA1*0301 haplotype: DR12-DQ7.5/DR7-DQ2.2 is a transhaplotype risk for coeliac disease

DRB11201:DRB301/03: colorectal cancer

Genetic Linkage

::data[format=table]

SerotypesDRADRB1DRB3SerotypesDRB1DQA1DQB1SerotypesHLA-AHLA-CHLA-BDRB1
DR11(5)-DR52*0101*1201*0101
*0101*1202*0201
*0101*1202*0202
*0101*1202*0301
DR12(5)-DQ7 (7.5, 3)*1201*0505*0301
*1202*0505*0301
DR12(5)-DQ7 (7.3, 3)*1201*0303*0301
DR12(5)-DQ7 (7.4, 3)*1201*0401*0301
DR12(5)-DQ7 (7.6, 3)*1201*0601*0301
A31(19)-Cw10-B51(5)-DR12(5)*3101*0304*5101*1202
A11-Cw9-B75(15)-DR12(5)*1101*0303*1502*1202
A2-Cw10-B13-DR12(5)*0201*0304*1301*1202
::

HLA-DR12 is genetically linked to DR52 and HLA-DQ7 serotypes.

References

References

  1. [http://www.ebi.ac.uk/imgt/hla/allele.html derived from IMGT/HLA]
  2. DR8 - 2%
  3. (2005). "The association between HLA DR, DQ antigens, and vulval lichen sclerosus in the UK: HLA DRB112 and its associated DRB112/DQB10301/04/09/010 haplotype confers susceptibility to vulval lichen sclerosus, and HLA DRB10301/04 and its associated DRB10301/04/DQB10201/02/03 haplotype protects from vulval lichen sclerosus.". J Invest Dermatol.
  4. (2007). "Human Leukocyte Antigens in Undifferentiated Spondyloarthritis". Seminars in Arthritis and Rheumatism.
  5. (1994). "Class II alleles in juvenile arthritis in Czech children.". J Rheumatol.
  6. (1995). "Association of HLA-DR5 (possibly DRB1*1201) with the primary antiphospholipid syndrome in Mexican patients.". Arthritis Rheum.
  7. (1994). "A possible linkage of HLA-DRB haplotypes with Tiopronin intolerance in rheumatoid arthritis". Clin. Exp. Rheumatol..
  8. (2001). "Cytokine and immunogenetic profiles in Japanese patients with adult Still's disease. Association with chronic articular disease.". Rheumatology (Oxford).
  9. (2006). "HLa-class II (DRB & DQB1) in Thai sudden unexplained death syndrome (Thai SUDS) families (Lai-Tai families)". Southeast Asian J. Trop. Med. Public Health.
  10. (1992). "HLA class II alleles associated with celiac disease susceptibility in a southern European population.". Tissue Antigens.
  11. (1992). "HLA genotyping of colorectal carcinoma in the Chinese population.". Hum Immunol.
  12. (2004). "HLA-DRB1 and -DRB3 allele frequencies and haplotypic associations in Koreans". Hum. Immunol..

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