HLA-DR52

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title: "HLA-DR52" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public tags: ["hla-dr-haplotypes"] topic_path: "general/hla-dr-haplotypes" source: "https://en.wikipedia.org/wiki/HLA-DR52" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0

HLA-DR52 is an HLA-DR serotype that recognizes gene products of HLA-DRB3 locus. Three allele groups can produce 35 isoforms.

DRB3, DRB4, and DRB5 are minor DR beta-encoding loci, and they have been recognized as having distinct evolution, having diverged from DRB1 around 4 million years ago.

The DRB3 locus is only apparent in a small subset of DR haplotypes, and most individuals lack DRB3.

Alleles

Associated diseases

DR52 serotype is positively associated with systemic sclerosis, inflammatory myopathies, inclusion body myositis,

DRB3*01 is positively associated with sarcoidosis, Grave's Disease, pulmonary sarcoidosis,

DRB301:01:DRB103:01 is linked to Lofgren's syndrome

DRB3*02:02 is also linked to Grave's disease, serum IgG antibodies to Chlamydia pneumoniae with essential hypertension, acute necrotizing encephalopathy

DRB3*03:01 is weakly associated with anticardiolipin antibodies in SLE

DRB303:01:DRB113:02 may be associated with Crohn's disease

DRB1 linkage

HLA-DRB3 is linked to these HLA-DR serotypes and DRB1 allele groups:

HLA-DR3 - DRB1*03

HLA-DR5 -

HLA-DR6 -

Rarely HLA-DR8 - DRB1*08

HLA-DR52 - Sjögren syndrome

References

References

  1. (1987). "Structural comparison of the genes of two HLA-DR supertypic groups: the loci encoding DRw52 and DRw53 are not truly allelic". Immunogenetics.
  2. (1996). "The HLA-DRB9 gene and the origin of HLA-DR haplotypes". Hum. Immunol..
  3. [http://www.ebi.ac.uk/imgt/hla/allele.html derived from IMGT/HLA]
  4. (1993). "The HLA-DR and DQ genes control the autoimmune response to DNA topoisomerase I in systemic sclerosis (scleroderma)". J. Clin. Invest..
  5. Garlepp MJ. (1993). "Immunogenetics of inflammatory myopathies". Baillière's Clinical Neurology.
  6. (1994). "HLA associations with inclusion body myositis". Clin. Exp. Immunol..
  7. (1995). "Clinical features of sarcoidosis in relation to HLA distribution and HLA-DRB3 genotyping by PCR-RFLP". The British Journal of Ophthalmology.
  8. (2001). "HLA-DRB3*0101 is associated with Graves' disease in Jamaicans". Clin. Endocrinol..
  9. (1999). "HLA-DRB108, DRB103/DRB30101, and DRB30202 are susceptibility genes for Graves' disease in North American Caucasians, whereas DRB1*07 is protective". J. Clin. Endocrinol. Metab..
  10. (2000). "Lung T-helper cells expressing T-cell receptor AV2S3 associate with clinical features of pulmonary sarcoidosis". Am. J. Respir. Crit. Care Med..
  11. (2001). "HLA-DRB103, DRB111 or DRB1*12 and their respective DRB3 specificities in clinical variants of sarcoidosis". Tissue Antigens.
  12. (2005). "Association of HLA-DRB3*0202 and serum IgG antibodies to Chlamydia pneumoniae with essential hypertension in a highly homogeneous population from Majorca (Balearic Islands, Spain)". J. Hum. Hypertens..
  13. (2004). "Molecular analysis of HLA class II-associated susceptibility to neuroinflammatory diseases in Korean children". J. Korean Med. Sci..
  14. Galeazzi M. (2000). "HLA class II alleles associations of anticardiolipin and antibeta2GPI antibodies in a large series of European patients with systemic lupus erythematosus". Lupus.
  15. Cariappa A. (1998). "Analysis of MHC class II DP, DQ and DR alleles in Crohn's disease". Gut.
  16. (August 1996). "Six new DR52-associated DRB1 alleles, three of DR8, two of DR11, and one of DR6, reflect a variety of mechanisms which generate polymorphism in the MHC.". Tissue Antigens.

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