HLA-DR13
title: "HLA-DR13" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public tags: ["hla-dr-haplotypes"] topic_path: "general/hla-dr-haplotypes" source: "https://en.wikipedia.org/wiki/HLA-DR13" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0
HLA-DR13(DR13) is a HLA-DR serotype that recognizes the DRB1*1301 to *13082, *1310 and some other *13 gene products. DR13 serotype is a split antigen of the older HLA-DR6 serotype group which also contains the similar HLA-DR14 antigens.
Alleles
Serotypes are unknown the following alleles: DRB1*1309, 1315 to 1379 **DRB113* allele group
- 81 Alleles: 74 proteins
- DR13 (weak or no DR6) Serotype: *1301, *1302, *1304, *1306, *1307, *1310, *1312 to *1314
- DR6 (weak DR13) Serotype: *1308
- DR13&Other serotypes: *1303, *1305, *1311,
- Serotype unknown: *1309, *1315 to *1374
Disease associations
DRB1*1302 is linked to early childhood myastenia gravis. Alleles of DR13 along with immunization for hepatitis B and C are most protective against the disease.
Extended linkage
DRB11302:DQA10102:DQB1*0604 Early childhood myastenia gravis
Genetic Linkage
::data[format=table]
| DRA | DRB1 | DRB3 | DQA1 | DQB1 | DRB1 | HLA-A | HLA-B | DRB1 |
|---|---|---|---|---|---|---|---|---|
| DR13(6)-DR52 | *0101 | *1301 | *0101 | |||||
| *0101 | *1301 | *0201 | ||||||
| *0101 | *1302 | *0301 | ||||||
| DR13(6)-DQ6(6.3, 1) | *0103 | *0603 | *1301 | |||||
| DR13(6)-DQ6(6.4, 1) | *0102 | *0604 | *1302 | |||||
| DR13(6)-DQ6(6.5, 1) | *0102 | *0605 | *1302 | |||||
| DR13(6)-DQ6(6.9, 1) | *0102 | *0609 | *1302 | |||||
| A2-Cw5-B44(16)-DR13 | *02 | *4402 | *1301 | |||||
| :: |
HLA-DR13 is genetically linked to DR52 and HLA-DQ6 (HLA-DQ1) serotypes.
References
References
- [http://www.ebi.ac.uk/imgt/hla/allele.html derived from IMGT/HLA]
- DR12 - 3%, DR11 - 3% DR5-2%
- DR12 - 6%, DR11 - 7% DR5-4%
- (2004). "A variant of childhood-onset myasthenia gravis: HLA typing and clinical characteristics in Japan.". Clin Immunol.
- (2004). "HLA-DRB1 and -DRB3 allele frequencies and haplotypic associations in Koreans". Hum. Immunol..
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