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5-MeO-AET

Chemical compound

Chemical compound

5-MeO-αET, also known as 5-methoxy-α-ethyltryptamine, is a psychoactive drug of the tryptamine and α-alkyltryptamine families. It reportedly produces psychedelic and stimulant effects.

Use and effects

The dose range of 5-MeO-αET is 50 to 75mg orally. 5-MeO-αET produces entactogenic and stimulant effects that can last 4 to 6hours. However, little information exists on the psychopharmacological effects of this compound, thus considerable variation with regard to dose and effects can be expected.

Interactions

Pharmacology

Pharmacodynamics

The pharmacology of 5-MeO-αET has been studied. It is a weak partial agonist of the serotonin 5-HT2A receptor, with a binding affinity (Ki) of 4,073nM, an of 166nM, and an of 34%. For comparison, αET showed 14-fold lower affinity for the receptor than 5-MeO-αET and was inactive as an agonist of the receptor. The individual stereoisomers of 5-MeO-αET and αET were also assessed.

Chemistry

Analogues

Analogues of 5-MeO-AET include α-ethyltryptamine (AET), α-methylserotonin (5-HO-AMT), 5-MeO-AMT, 4-methyl-AET, 5-fluoro-AET, 5-EtO-AMT, 5-fluoro-AET, 5-chloro-AET, and 7-methyl-AET, among others.

Society and culture

Canada

5-MeO-AET is not a controlled substance in Canada as of 2025.

United States

5-MeO-αET is unscheduled and uncontrolled in the United States, but possession and sales of 5-MeO-αET could be prosecuted under the Federal Analog Act because of its structural similarities to αET and αMT.

References

References

  1. (2003). "Hallucinogens: A Forensic Drug Handbook". Elsevier Science.
  2. (December 2012). "Identifying emerging trends in recreational drug use; outcomes from the Psychonaut Web Mapping Project". Elsevier BV.
  3. Jones, Charles. (2024). "Exploration of Dopaminergic and Serotonergic Pathways Utilizing Pleiotropic Agents". VCU Libraries.
  4. "Controlled Drugs and Substances Act".
Info: Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

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