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2CBFly-NBOMe

Field	Value
Verifiedfields	changed
Watchedfields	changed
verifiedrevid	452171769
image	2CBFly-NBOMe-2D.svg
image_class	skin-invert-image
width	250px
image2	2CBFly-NBOMe-3D-balls.png
image_class2	bg-transparent
width2	250px
class	Serotonin receptor modulator; Serotonin 5-HT2A receptor agonist
ATC_prefix	None
CAS_number_Ref
CAS_number	1335331-42-4
PubChem	57469208
ChemSpiderID	26234936
ChemSpiderID_Ref
synonyms	2C-B-FLY-NBOMe; NBOMe-2C-B-FLY; Cimbi-31; N-(2-Methoxybenzyl)-2C-B-FLY
IUPAC_name	2-(8-bromo-2,3,6,7-tetrahydrobenzo[1,2-b:4,5-b′]difuran-4-yl)-N-[(2-methoxyphenyl)methyl]ethan-1-amine
C	20	H=22	Br=1	N=1	O=3
SMILES	COc1ccccc1CNCCc1c2CCOc2c(Br)c2CCOc12
StdInChI	1S/C20H22BrNO3/c1-23-17-5-3-2-4-13(17)12-22-9-6-14-15-7-10-25-20(15)18(21)16-8-11-24-19(14)16/h2-5,22H,6-12H2,1H3
StdInChI_Ref
StdInChIKey	CUFCITSPWAZWHS-UHFFFAOYSA-N
StdInChIKey_Ref

| Drugs.com =

| elimination_half-life =

2CBFly-NBOMe, also known as NBOMe-2C-B-FLY or as Cimbi-31, is a serotonin receptor modulator of the phenethylamine, DOx, and FLY families. It was indirectly derived from the phenethylamine hallucinogen 2C-B is and related to benzodifurans like 2C-B-FLY and N-benzylphenethylamines like 25B-NBOMe.

Interactions

Pharmacology

Pharmacodynamics

2CBFly-NBOMe acts as a potent partial agonist for the 5-HT2A serotonin receptor subtype.

History

2CBFly-NBOMe was discovered in 2002, and further researched by Ralf Heim at the Free University of Berlin, and subsequently investigated in more detail by a team at Purdue University led by David E. Nichols.

Society and culture

Legal status

Canada

2CBFly-NBOMe is a controlled substance in Canada under phenethylamine blanket-ban language.

United Kingdom

United States

2CBFly-NBOMe is not an explicitly controlled substance in the United States. However, it could be considered a controlled substance under the Federal Analogue Act if intended for human consumption.

2CBFly-NBOMe is a controlled substance in Vermont as of January 2016.

References

(January 2011). "Theoretical studies on the interaction of partial agonists with the 5-HT2A receptor". Journal of Computer-Aided Molecular Design.
Hansen, Martin. (2011). "Design and Synthesis of Selective Serotonin Receptor Agonists for Positron Emission Tomography Imaging of the Brain". University of Copenhagen.
(2002). "Development of highly potent partial agonists and chiral antagonists as tools for the study of 5-HT2A-receptor mediated function". Naunyn-Schmiedeberg's Archives of Pharmacology.
Heim, Ralf. (2004). "Synthese und Pharmakologie potenter 5-HT2A-Rezeptoragonisten mit N-2-Methoxybenzyl-Partialstruktur. Entwicklung eines neuen Struktur-Wirkungskonzepts". Free University of Berlin.
Braden, Michael Robert. (2007). "Towards a biophysical understanding of hallucinogen action". Purdue University.
"Controlled Drugs and Substances Act".
(January 2026). "Orange Book: List of Controlled Substances and Regulated Chemicals (January 2026)". U.S. [[Department of Justice]]: [[Drug Enforcement Administration]] (DEA): Diversion Control Division.
"Regulated Drugs Rule". Vermont Department of Health.

Info: Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

5-ht2a-agonists 25-nb-(psychedelics) 2c-(psychedelics) bromobenzene-derivatives david-e.-nichols dihydrofurans fly-(psychedelics) heterocyclic-compounds-with-3-rings 2-methoxyphenyl-compounds psychedelic-phenethylamines secondary-amines serotonin-receptor-agonists

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