HLA-B58

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title: "HLA-B58" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public tags: ["hla-b-alleles", "drug-sensitivity-genes"] description: "Human leukocyte antigen serotype" topic_path: "general/hla-b-alleles" source: "https://en.wikipedia.org/wiki/HLA-B58" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0

::summary Human leukocyte antigen serotype ::

::data[format=table]

Locus	chr.6 6p21.31
::

HLA-B58 (B58) is an HLA-B serotype. B58 is a split antigen from the B17 broad antigen, the sister serotype B57. The serotype identifies the more common HLA-B58 gene products. (For terminology help see: HLA-serotype tutorial) B5801 is associated with allopurinol induced inflammatory necrotic skin disease.

Serotype

::data[format=table title="B58 and B17 serotype recognition of some more common HLA B*58 alleles[http://www.ebi.ac.uk/imgt/hla/allele.html derived from IMGT/HLA]"]

5802	72	3	837
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Allele distribution

::data[format=table title="'''HLA B*5801 frequencies'''"]

	Tunisia	1.0
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Disease

HLA-B*5801 is involved in allopurinol sensitive drug induced Stevens–Johnson syndrome. Allopurinol is a frequent cause of severe cutaneous adverse reactions, including drug-hypersensitivity syndrome, Stevens–Johnson syndrome, and toxic epidermal necrolysis (SJS/TEN). The association with allopurinol sensitivity in SJS/TEN was extremely strong in Asia, and somewhat less associated in Europeans.

References

References

1. (1985). "The complete primary structure of HLA-Bw58". J. Biol. Chem..
2. (2010). "Nomenclature for factors of the HLA system, 2010". Tissue Antigens.
3. [http://www.ebi.ac.uk/imgt/hla/allele.html derived from IMGT/HLA]
4. (2003). "New allele frequency database". Tissue Antigens.
5. (August 2007). "Human leukocyte antigens and drug hypersensitivity". Curr Opin Allergy Clin Immunol.
6. (2009). "Strong association between HLA-B*5801 and allopurinol-induced Stevens–Johnson syndrome and toxic epidermal necrolysis in a Thai population". Pharmacogenet Genomics.
7. Hung SI. (March 2005). "HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol". Proc. Natl. Acad. Sci. U.S.A..
8. Lonjou C. (February 2008). "A European study of HLA-B in Stevens–Johnson syndrome and toxic epidermal necrolysis related to five high-risk drugs". Pharmacogenet. Genomics.

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