HLA-B39

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Human leukocyte antigen serotype

title: "HLA-B39" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public tags: ["hla-b-alleles"] description: "Human leukocyte antigen serotype" topic_path: "general/hla-b-alleles" source: "https://en.wikipedia.org/wiki/HLA-B39" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0

::summary Human leukocyte antigen serotype ::

::data[format=table]

Locuschr.6 6p21.31
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HLA-B39 (B39) is an HLA-B serotype. The serotype identifies the more common HLA-B*39 gene products.

B39 is a split antigen of the broad antigen B16, and is a sister type of B38. B39 is most commonly found on the west pacific rim, in Japan and highest frequency in the new world. In Europe it is found in Scandinavia and Northern Russia.

Serotype

::data[format=table title="Serotypes B39, B16, and B38 recognition of the
HLA B*39 gene products[http://www.ebi.ac.uk/imgt/hla/allele.html derived from IMGT/HLA]"]

Alleles link-out to IMGT/HLA Databease at EBI
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The serology for the most common B39 alleles, B3901 and B3906 is good, but some allele products are not well detected. Given the differential involvement of these alleles in disease testing should involve high resolution typing.

::data[format=table title="'''HLA B*3906 frequencies'''"]

Thailand0.4
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Alleles

::data[format=table title="'''HLA B*3901 frequencies'''"]

Finland1.1
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Disease

B39 is suggested as a factor in Takayasu's arteritis and gallstones in Mexico. Osteoarticular complications of brucellosis appear to be associated with B39. An association with spondylarthropathies and psoriatic arthritis was observed in several studies. Psoriatic arthritis appears to be linked to MICA-A9 which tightly linked to HLA-B39. B39 also appears to be involved in the Fishers syndrome variant of Guillain–Barré syndrome.

B39 appears to be protective against cardiomyopathy in Chaga's disease indicating a possible selective factor in its rise in the New World. Chaga's disease is caused by a trypanosome carried by a blood sucking insect found in tropical, palm growing regions.

Southern California now reports cases of Chaga's disease from contaminated transfusions and may be already a habitat for the vector.

In Takayasu's arteritis

Takayasu's arteritis appears to have a link to B39. The association with B3902 increases risk of pulmonary infarction, ischemic heart disease, aortic regurgitation, systemic hypertension, renal artery stenosis, cerebrovascular disease, and visual disturbance. B3906, common in indigenous Mesoamericans has been found associated with the same disease.

::data[format=table title="'''HLA B*3902 frequencies'''"]

B*3903B*3904B*3905B*3907B*3908B*3909B*3910
PNG New Britain Rabaul13.2
Brazil Terena11.2
Argentina Toba Rosario5.2
Brazil0.7
Finland0.6
Kenya Luo0.6
North American Natives0.5
Argentina Toba Rosario1.2
Georgia Svaneti Svans0.6
Jordan Amman0.3
Shijiazhuang Tianjian Han0.1
Japan Central0.1
Romanian0.1
Venezuela Perija Yucpa36.1
Mexico Zaptotec Oaxaca12.7
Mexico Mixtec Oaxaca9.8
Mexico Mestizos4.9
Arizona Pima4.5
Mexico Guadalajara Mestizos2.4
Argentina Toba Rosario2.3
USA Hispanic2.1
Mexico Mixe Oaxaca1.9
Cuban White1.4
Mexico Chihuahua Tarahumara1.1
USA North American Natives0.5
Shijiazhuang Tianjian Han0.2
Shijiazhuang Tianjian Han0.6
Singapore Thai0.5
China South Han0.2
Mexico Zaptotec Oaxaca2.2
Mexico Mestizos1.2
Mexico Mixtec Oaxaca1.0
Brazil0.7
USA Hispanic0.6
Venezuela Perija Yucpa34.9
Thailand pop33.1
Brazil Terena1.7
China South Han1.4
Argentina Toba Rosario1.2
China Qinghai Hui0.9
Sudanese2.5
Senegal Niokholo Mandenka2.1
South African Natal Zulu1.5
Cameroon Beti1.4
Spain Eastern Andalusia1.2
Kenya Luo1.1
Israel Arab Druse1.0
Kenya Nandi1.0
Guinea Bissau0.8
Kenya0.7
Mali Bandiagara0.7
Morocco Nador Metalsa Class I0.7
Cameroon Bamileke0.6
Cameroon Yaounde0.5
Israel Ashk. and Non Ashk. Jews0.5
Saudi Arabia Guraiat and Hail0.5
::

References

References

  1. (2010). "Nomenclature for factors of the HLA system, 2010". Tissue Antigens.
  2. [http://www.ebi.ac.uk/imgt/hla/allele.html derived from IMGT/HLA]
  3. (2003). "New allele frequency database". Tissue Antigens.
  4. (November 2004). "The Amerindian's genes in the Mexican population are associated with development of gallstone disease". Am. J. Gastroenterol..
  5. (May 2003). "HLA-B*39 allele confers susceptibility to osteoarticular complications in human brucellosis". J. Rheumatol..
  6. (January 1999). "Overlapping peptide-binding specificities of HLA-B27 and B39: evidence for a role of peptide supermotif in the pathogenesis of spondylarthropathies". Arthritis Rheum..
  7. (July 2000). "HLA-B27 and immunogenetics of spondyloarthropathies". Curr Opin Rheumatol.
  8. Eastmond CJ. (May 1994). "Psoriatic arthritis. Genetics and HLA antigens". Baillière's Clinical Rheumatology.
  9. (June 1995). "The role of HLA antigens as indicators of disease progression in psoriatic arthritis. Multivariate relative risk model". Arthritis Rheum..
  10. (October 2001). "MICA and MICB microsatellite alleles in HLA extended haplotypes". Eur. J. Immunogenet..
  11. (May 2002). "MICA rather than MICB, TNFA, or HLA-DRB1 is associated with susceptibility to psoriatic arthritis". J. Rheumatol..
  12. (June 1993). "Human leukocyte antigens in Fisher's syndrome". Ann. Neurol..
  13. (January 2004). "MHC class I and class II genes in Mexican patients with Chagas disease". Hum. Immunol..
  14. "Chagas Disease Represents New Challenge for Blood Supply Safety".
  15. (August 1996). "Comprehensive analysis of HLA genes in Takayasu arteritis in Japan". Int. J. Cardiol..
  16. (August 1993). "DNA typing of HLA-B gene in Takayasu's arteritis". Tissue Antigens.
  17. (October 1998). "Association of clinical manifestations with HLA-B alleles in Takayasu arteritis". Int. J. Cardiol..
  18. (October 1998). "Intron 2 and exon 3 sequences may be involved in the susceptibility to develop Takayasu arteritis". Int. J. Cardiol..

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