HLA-B38

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Human leukocyte antigen serotype

title: "HLA-B38" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public tags: ["hla-b-alleles"] description: "Human leukocyte antigen serotype" topic_path: "general/hla-b-alleles" source: "https://en.wikipedia.org/wiki/HLA-B38" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0

::summary Human leukocyte antigen serotype ::

::data[format=table]

Locuschr.6 6p21.31
::

HLA-B38 (B38) is an HLA-B serotype. The serotype identifies the B*38 allele products of the HLA-B gene-locus.

B38 is a split antigen of the broad antigen B16, and is a sister type of B39. The B3801 allele is more common in Eastern, Southern and Southeastern Europe, while the B3802 allele is more common in the Far East.

Serotype

::data[format=table title="Serotypes B38, B16, and B39 recognition of the
HLA B*39 gene products[http://www.ebi.ac.uk/imgt/hla/allele.html derived from IMGT/HLA]"]

Alleles link-out to IMGT/HLA Databease at EBI
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Alleles

::data[format=table title="'''HLA B*3801 frequencies'''"]

Ireland South0.8
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Disease

A higher frequency of HLA-B38 was noted psoriatic arthritis patients with erythroderma. Psoriatic arthritis is linked to MICA and/or B39 in other peoples. In Pemphigus vulgaris a haplotype containing B38 was identified and found to be shared between Spanish and Jewish patients. Linkage studies indicate a factor in the HLA-class I region is more greatly associated, with HLA-B38 so far the only linked allele

::data[format=table title="'''HLA B*3802 frequencies'''"]

Brazil0.7
::

References

References

  1. (2010). "Nomenclature for factors of the HLA system, 2010". Tissue Antigens.
  2. [http://www.ebi.ac.uk/imgt/hla/allele.html derived from IMGT/HLA]
  3. (2003). "New allele frequency database". Tissue Antigens.
  4. (December 2006). "[Genetics in patients with psoriatic arthritis]". Orv Hetil.
  5. Eastmond CJ. (May 1994). "Psoriatic arthritis. Genetics and HLA antigens". Baillière's Clinical Rheumatology.
  6. (April 2004). "Common ancestral origin of pemphigus vulgaris in Jews and Spaniards: a study using microsatellite markers". Tissue Antigens.
  7. (August 2003). "Pemphigus vulgaris in Jewish patients is associated with HLA-A region genes: mapping by microsatellite markers". Hum. Immunol..

::callout[type=info title="Wikipedia Source"] This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page. ::

hla-b-alleles