HLA-B57

---

title: "HLA-B57" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public tags: ["hla-b-alleles", "drug-sensitivity-genes"] description: "Human leukocyte antigen serotype" topic_path: "general/hla-b-alleles" source: "https://en.wikipedia.org/wiki/HLA-B57" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0

::summary Human leukocyte antigen serotype ::

::data[format=table]

Locus	chr.6 6p21.31
::

HLA-B57 (B57) is an HLA-B serotype. B57 is a split antigen from the B17 broad antigen, the sister serotype being B58. The serotype identifies the more common HLA-B*57 gene products. (For terminology help see: HLA-serotype tutorial.) Like B58, B57 is involved in drug-induced inflammatory skin disorders.

Disease

HLA-B*5701 is associated with drug-induced inflammatory disease of the skin. Individuals with B57 are more sensitive to the drug abacavir. Abacavir is an antiretroviral drug used in treatment of HIV, however in sensitive individuals fever, skin rash, fatigue, gastrointestinal symptoms such as nausea, vomiting, diarrhea or abdominal pain and respiratory symptoms such as pharyngitis, dyspnea, or cough can develop. FDA has advised that people from at-risk ethnic groups, (see alle distribution table) be screened prior to drug-therapy. [Note: phenotype frequencies are roughly double allele frequencies -tabled values- when allele frequency is less than 30%]

The mechanism by which abacavir causes this type 4 hypersensitivity reaction is by binding in the antigen-binding cleft of the HLA-B*57:01 protein, allowing new, "non-self" antigens to bind and be presented to T cells.

Serotype

::data[format=table title="B57 and B17 serotype recognition of some more common HLA B*57 alleles[http://www.ebi.ac.uk/imgt/hla/allele.html derived from IMGT/HLA]"]

5704	67	7	32
::

Allele distribution

::data[format=table title="'''HLA B*5701 frequencies'''"]

	USA Asian	1.0
::

::data[format=table title="'''HLA B*5702 frequencies'''"]

	Saudi Arabia Guraiat and Hail	1.5
::

References

References

1. (2010). "Nomenclature for factors of the HLA system, 2010". Tissue Antigens.
2. (1985). "The complete primary structure of HLA-Bw58". J. Biol. Chem..
3. (August 2007). "Human leukocyte antigens and drug hypersensitivity". Curr Opin Allergy Clin Immunol.
4. [https://web.archive.org/web/20080916141240/http://www.fda.gov/cder/drug/InfoSheets/HCP/abacavirHCP.htm fda.gov] FDA abacavir alert web access July 29, 2008
5. (2012-06-28). "Immune self-reactivity triggered by drug-modified HLA-peptide repertoire". Nature.
6. [http://www.ebi.ac.uk/imgt/hla/allele.html derived from IMGT/HLA]
7. (2003). "New allele frequency database". Tissue Antigens.

::callout[type=info title="Wikipedia Source"] This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page. ::