Ganoderic acid

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title: "Ganoderic acid" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public tags: ["5α-reductase-inhibitors", "triterpenes", "cyclohexenols", "keto-acids", "sterols", "enones"] topic_path: "general/5a-reductase-inhibitors" source: "https://en.wikipedia.org/wiki/Ganoderic_acid" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0

| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 428815571 | Name=Ganoderic acid A | ImageFile=Ganoderic acid.png | ImageSize=200px | IUPACName = (25R)-7β,15α-Dihydroxy-3,11,23-trioxolanost-8-en-26-oic acid | SystematicName = (2R,6R)-6-[(1R,3S,3aR,4S,5aR,9aS,11aR)-3,4-Dihydroxy-3a,6,6,9a,11a-pentamethyl-7,10-dioxo-2,3,3a,4,5,5a,6,7,8,9,9a,10,11,11a-tetradecahydro-1H-cyclopenta[a]phenanthren-1-yl]-2-methyl-4-oxoheptanoic acid | OtherNames = |Section1={{Chembox Identifiers | CASNo_Ref = | CASNo=81907-62-2 | UNII_Ref = | UNII = 548G37DF65 | PubChem=471002 | ChemSpiderID_Ref = | ChemSpiderID = 413668 | SMILES = OC(=O)C@HCC(=O)CC@@H[C@H]2CC@H[C@@]1(C)C/3=C(\C(=O)C[C@@]12C)[C@@]4(C)CCC(=O)C@(C)[C@@H]4C[C@@H]\3O | InChI = 1/C30H44O7/c1-15(10-17(31)11-16(2)26(36)37)18-12-23(35)30(7)25-19(32)13-21-27(3,4)22(34)8-9-28(21,5)24(25)20(33)14-29(18,30)6/h15-16,18-19,21,23,32,35H,8-14H2,1-7H3,(H,36,37)/t15-,16-,18-,19+,21+,23+,28+,29-,30+/m1/s1 | InChIKey = DYOKDAQBNHPJFD-JNTBEZBXBK | StdInChI_Ref = | StdInChI = 1S/C30H44O7/c1-15(10-17(31)11-16(2)26(36)37)18-12-23(35)30(7)25-19(32)13-21-27(3,4)22(34)8-9-28(21,5)24(25)20(33)14-29(18,30)6/h15-16,18-19,21,23,32,35H,8-14H2,1-7H3,(H,36,37)/t15-,16-,18-,19+,21+,23+,28+,29-,30+/m1/s1 | StdInChIKey_Ref = | StdInChIKey = DYOKDAQBNHPJFD-JNTBEZBXSA-N |Section2={{Chembox Properties | Formula=C30H44O7 | MolarMass=516.67 | Appearance= | Density= | MeltingPt= | BoilingPt= | Solubility= |Section3={{Chembox Hazards | MainHazards= | FlashPt= | AutoignitionPt =

Ganoderic acids are a class of closely related triterpenoids (derivatives from lanosterol) found in Ganoderma mushrooms. For thousands of years, the fruiting bodies of Ganoderma fungi have been used in traditional medicines in East Asia. Consequently, there have been efforts to identify the chemical constituents that may be responsible for the putative pharmacological effects. The two most well described ganoderic acids out of the many that have been identified and characterized are ganoderic acids A and B. Some ganoderic acids have been found to possess biological activities including hepatoprotection, anti-tumor effects, and 5-alpha reductase inhibition.

References

References

  1. (1989). "Bitter triterpenoids from the fungus Ganoderma applanatum". Phytochemistry.
  2. (2014). "Triterpenoids of Ganoderma theaecolum and their hepatoprotective activities". Fitoterapia.

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5α-reductase-inhibitorstriterpenescyclohexenolsketo-acidssterolsenones