Hepatoprotection

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Ability of a chemical substance to prevent liver damage

title: "Hepatoprotection" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public tags: ["hepatology"] description: "Ability of a chemical substance to prevent liver damage" topic_path: "general/hepatology" source: "https://en.wikipedia.org/wiki/Hepatoprotection" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0

::summary Ability of a chemical substance to prevent liver damage ::

Hepatoprotection or antihepatotoxicity is the ability of a chemical substance to prevent damage to the liver. This is opposite to hepatotoxicity.

Hepatoprotective molecules used in emergency medicine

Acetylcysteine is considered the hepatoprotective drug of choice when treating an overdose of acetaminophen/paracetamol.
Silymarin is given intravenously to treat poisoning from Amanita mushrooms according to the Santa Cruz protocol devised by Dr Todd Mitchell at UCSC.

Herbs with potentially hepatoprotective constituents

Astragalus membranaceus
Brassica
Silybum marianum, from which silymarin is derived
Andrographis paniculata

References

"Archived copy".
(Jan 2011). "Biological analysis of herbal medicines used for the treatment of liver diseases.". Biomedical Chromatography.
(Sep 1, 2001). "Effects of cruciferous vegetables and their constituents on drug metabolizing enzymes involved in the bioactivation of DNA-reactive dietary carcinogens.". Mutation Research.
Andrographis paniculata http://www.stuartxchange.com/Sinta.html

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