Acrivastine
Chemical compound
title: "Acrivastine" type: doc version: 1 created: 2026-02-28 author: "Wikipedia contributors" status: active scope: public tags: ["h1-receptor-antagonists", "disubstituted-pyridines", "1-pyrrolidinyl-compounds", "alkene-derivatives", "peripherally-selective-drugs", "4-tolyl-compounds"] description: "Chemical compound" topic_path: "general/h1-receptor-antagonists" source: "https://en.wikipedia.org/wiki/Acrivastine" license: "CC BY-SA 4.0" wikipedia_page_id: 0 wikipedia_revision_id: 0
::summary Chemical compound ::
| Verifiedfields = changed | verifiedrevid = 477241254 | IUPAC_name = (E)-3-{6-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-yl- prop-1-enyl]pyridin-2-yl}prop-2-enoic acid | image = Acrivastine.svg | image_class = skin-invert-image
| tradename = | Drugs.com = | pregnancy_AU = | legal_AU = | legal_CA = | legal_UK = GSL | legal_US = Rx-only | routes_of_administration = By mouth
| elimination_half-life = 1.5 hours | excretion = Kidney
| CAS_number_Ref = | CAS_number = 87848-99-5 | ATC_prefix = R06 | ATC_suffix = AX18 | PubChem = 5284514 | DrugBank_Ref = | ChemSpiderID_Ref = | ChemSpiderID = 4447574 | UNII_Ref = | UNII = A20F9XAI7W | KEGG_Ref = | KEGG = D02760 | ChEMBL_Ref = | ChEMBL = 1224 | ChEBI_Ref = | ChEBI = 83168
| C=22 | H=24 | N=2 | O=2 | smiles = O=C(O)\C=C\c3nc(\C(=C\CN1CCCC1)c2ccc(cc2)C)ccc3 | StdInChI_Ref = | StdInChI = 1S/C22H24N2O2/c1-17-7-9-18(10-8-17)20(13-16-24-14-2-3-15-24)21-6-4-5-19(23-21)11-12-22(25)26/h4-13H,2-3,14-16H2,1H3,(H,25,26)/b12-11+,20-13+ | StdInChIKey_Ref = | StdInChIKey = PWACSDKDOHSSQD-IUTFFREVSA-N Acrivastine is a medication used for the treatment of allergies and hay fever. It is a second-generation H1-receptor antagonist antihistamine (like its base molecule triprolidine) and works by blocking histamine H1 receptors.
This non-sedating antihistamine is sold under the brand name Benadryl Allergy Relief in the United Kingdom by McNeil Laboratories. It should not be confused with Benadryl Once a Day which has cetirizine as the active ingredient and is also sold by McNeil in the UK, nor with the American Benadryl, which uses diphenhydramine as its active ingredient. It is available as an over-the-counter medicine in the UK, and is available with or without pseudoephedrine under the Benadryl brand.
In the U.S., acrivastine was the active ingredient in Semprex-D. Semprex-D also contains the decongestant pseudoephedrine. Semprex-D was marketed in the U.S. by Actient Pharmaceuticals. Neither version of Semprex-D have been manufactured for sale in the US since 2008.
Comparisons with other popular antihistamines
Unlike cetirizine or loratadine, for which the standard dose is one tablet per day, a single acrivastine tablet may be taken up to three times a day. It is not to be taken by people over the age of 65, pregnant women, or people with compromised liver or kidney function.
References
References
- (June 1991). "Acrivastine. A review of its pharmacological properties and therapeutic efficacy in allergic rhinitis, urticaria and related disorders". Drugs.
- [https://web.archive.org/web/20090514122438/http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=7627 SEMPREX-D - acrivastine and pseudoephedrine hydrochloride capsule] U.S. [[National Library of Medicine]], National Institutes of Health, May 2008
- (2014). "Benadryl Allergy Relief". electronic Medicines Compendium (eMC).
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