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Zibotentan

Zibotentan (INN; development code ZD4054) is an experimental anti-cancer drug candidate in development by AstraZeneca. It is an endothelin receptor antagonist.

Zibotentan was granted fast track status for the treatment of prostate cancer by the FDA.

It failed a phase III clinical trial for prostate cancer, but other trials are planned. Tolerability of zibotentan plus docetaxel has been evaluated.

Zibotentan has also been studied in clinical trials for treatment of breast cancer, colorectal cancer, non-small cell lung cancer, ovarian cancer, scleroderma-related renal disease, bone metastasis, and heart failure.

References

References

  1. James and Growcott. (2009). "Drugs of the Future".
  2. (2011). "Pharmacokinetics and tolerability of zibotentan (ZD4054) in subjects with hepatic or renal impairment: two open-label comparative studies". BMC Clin Pharmacol.
  3. "AZ's zibotentan flunks late-stage prostate cancer trial - FierceBiotech".
  4. (28 September 2010). "Pfizer, AstraZeneca, and Actelion Separately Report Phase III Trial Failures - GEN".
  5. (September 2011). "Preliminary study of the specific endothelin a receptor antagonist zibotentan in combination with docetaxel in patients with metastatic castration-resistant prostate cancer". Prostate.
  6. "A Phase II, Single Centre, Randomised, Placebo-controlled, 3-part Trial to Assess the Safety, Tolerability and Efficacy of Zibotentan in Patients With Renal Disease Secondary to Scleroderma - AdisInsight".
  7. "Zibotentan - AdisInsight".
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experimental-cancer-drugs oxadiazoles disubstituted-pyridines sulfonamides pyrazines endothelin-receptor-antagonists para-phenylene-compounds biaryls
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