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Vitamin D analogues

Group of chemical compounds

Group of chemical compounds

The natural, active form of vitamin D is calcitriol (1,25-dihydroxycholecalciferol). This molecule and other naturally occurring forms of vitamin D, including its precursors and metabolites, have been modified to synthesize pharmaceuticals with potentially greater, or selective, therapeutic actions.

Types

These include:

  • Alfacalcidol
  • Calcipotriol (calcipotriene)
  • Doxercalciferol
  • Falecalcitriol
  • Paricalcitol
  • Tacalcitol

Mechanisms

These modified vitamin D analogues have a side chain or other modifications. They aim to reduce the classical renal and intestinal effects of calcitriol on calcium and phosphate homeostasis, from its effects on other biologic processes. They target cell proliferation and differentiation, especially in skin, or other effects in the parathyroid gland (secondary hyperparathyroidism) or bone cells.

References

References

  1. (April 2000). "Systematic review of comparative efficacy and tolerability of calcipotriol in treating chronic plaque psoriasis". BMJ (Clinical Research Ed.).
  2. (November 2001). "Vitamin D analogues for the management of secondary hyperparathyroidism". American Journal of Kidney Diseases.
  3. (May 2010). "Vitamine D analogue-based therapies for psoriasis". Drugs of Today.
  4. (April 2008). "Cellular and molecular mechanisms involved in the action of vitamin D analogs targeting vitiligo depigmentation". Current Drug Targets.
  5. (March 2014). "Vitamin D metabolism, mechanism of action, and clinical applications". Chemistry & Biology.
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