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Vitamin A2

Vitamin A2 is a subcategory of vitamin A.

As with all vitamin A forms, A2 can exist as an aldehyde, Dehydroretinal (3,4-dehydroretinal), an alcohol, 3,4-dehydroretinol (vitamin A2 alcohol) or an acid, 3,4-dehydroretinoic acid (vitamin A2 acid). Many cold-blooded vertebrates use the aldehyde for their visual system to obtain a red-shifted sensitive spectrum.

Human skin naturally contains the alcohol form. In humans, CYP27C1 converts ordinary A1 (all-trans retinoids) to A2. The enzyme also converts 11-cis-retinal.

Vitamin A2 was first identified by Richard Alan Morton using newly-developed absorption spectroscopy in 1941.

References

References

  1. (2016). "The Biochemical Basis of Vitamin A3 Production in Arthropod Vision". ACS Chem Biol.
  2. (1985). "Biosynthesis of 3-dehydroretinol (vitamin A2) from all-trans-retinol (vitamin A1) in human epidermis". J Invest Dermatol.
  3. (1980). "The identification of dehydroretinol (vitamin A2) in human skin". Experientia.
  4. (May 2016). "Human cytochrome P450 27C1 catalyzes 3,4-desaturation of retinoids.". FEBS Letters.
  5. (1977). "R. A. Morton". Nature.
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