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VIS1

Gene in the species Homo sapiens

VIS1 (viral integration site 1), also known as HIS-1, is a long non-coding RNA. It was originally identified in mice in a screen for genes involved in the development of myeloid leukemia. In murine myeloid leukemias, this gene is a common site of viral insertion by the murine ecotropic retrovirus CasBrM It is conserved amongst vertebrates, including human, mice, cats, pigs, cattle and dogs. Expression of VIS1 is restricted to epithelial cells, leukemias and carcinomas.

References

(November 1991). "His-1 and His-2: identification and chromosomal mapping of two commonly rearranged sites of viral integration in a myeloid leukemia". Oncogene.
(March 1994). "Retroviral insertions in the murine His-1 locus activate the expression of a novel RNA that lacks an extensive open reading frame". Mol. Cell. Biol..
(January 1997). "Evolutionary conservation of putative functional domains in the human homolog of the murine His-1 gene". Gene.
(April 1997). "Expression of the putative proto-oncogene His-1 in normal and neoplastic tissues". Am. J. Pathol..

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non-coding-rna

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