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Very-long-chain enoyl-CoA reductase

Class of enzymes

Class of enzymes

FieldValue
NameVery-long-chain enoyl-CoA reductase
EC_number1.3.1.93

Very-long-chain enoyl-CoA reductase (, TSC13 (gene name), CER10 (gene)) is an enzyme with systematic name very-long-chain acyl-CoA:NADP+ oxidoreductase. This enzyme catalyses the following chemical reaction

: a very-long-chain acyl-CoA + NADP+ \rightleftharpoons a very-long-chain trans-2,3-dehydroacyl-CoA + NADPH + H+

This is the fourth component of the elongase, a microsomal protein complex responsible for extending palmitoyl-CoA and stearoyl-CoA.

References

References

  1. (January 2001). "Tsc13p is required for fatty acid elongation and localizes to a novel structure at the nuclear-vacuolar interface in Saccharomyces cerevisiae". Molecular and Cellular Biology.
  2. (February 2004). "Functional characterization of the Arabidopsis thaliana orthologue of Tsc13p, the enoyl reductase of the yeast microsomal fatty acid elongating system". Journal of Experimental Botany.
  3. (September 2005). "Targeting of Tsc13p to nucleus-vacuole junctions: a role for very-long-chain fatty acids in the biogenesis of microautophagic vesicles". Molecular Biology of the Cell.
  4. (May 2005). "Disruptions of the Arabidopsis Enoyl-CoA reductase gene reveal an essential role for very-long-chain fatty acid synthesis in cell expansion during plant morphogenesis". The Plant Cell.
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