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Very-long-chain acyl-CoA dehydrogenase


FieldValue
NameVery-long-chain acyl-CoA dehydrogenase
EC_number1.3.8.9
image2uxw.jpg
width270
captionVery long chain acyl-CoA dehydrogenase dimer, Human

Very-long-chain acyl-CoA dehydrogenase (, ACADVL (gene).) is an enzyme with systematic name very-long-chain acyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase. This enzyme catalyses the following chemical reaction

: a very-long-chain acyl-CoA + electron-transfer flavoprotein \rightleftharpoons a very-long-chain trans-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein

This enzyme contains FAD as prosthetic group.

References

References

  1. (January 1992). "Novel fatty acid beta-oxidation enzymes in rat liver mitochondria. I. Purification and properties of very-long-chain acyl-coenzyme A dehydrogenase". The Journal of Biological Chemistry.
  2. (June 1995). "Purification of human very-long-chain acyl-coenzyme A dehydrogenase and characterization of its deficiency in seven patients". The Journal of Clinical Investigation.
  3. (April 2008). "Structural basis for substrate fatty acyl chain specificity: crystal structure of human very-long-chain acyl-CoA dehydrogenase". The Journal of Biological Chemistry.
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