Surf Wiki
Save to docs
general/ec-1-1-1

From Surf Wiki (app.surf) — the open knowledge base

UDP-glucose 6-dehydrogenase

Mammalian protein found in humans

Mammalian protein found in humans

UDP-glucose 6-dehydrogenase is a cytosolic enzyme that in humans is encoded by the UGDH gene.

The protein encoded by this gene converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated compounds are common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and cancer growth and metastasis. The expression of this gene is up-regulated by transforming growth factor beta and down-regulated by hypoxia.

This enzyme participates in 4 metabolic pathways: pentose and glucuronate interconversions, ascorbate and aldarate metabolism, starch and sucrose metabolism, and nucleotide sugars metabolism.

Loss of UGDH has recently been implicated in epileptic encephalopathy in humans

Nomenclature

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is UDP-glucose:NAD+ 6-oxidoreductase.

Other names in common use include:

  • UDP-glucose dehydrogenase,
  • uridine diphosphoglucose dehydrogenase,
  • UDPG dehydrogenase,
  • UDPG:NAD oxidoreductase,
  • UDP-alpha-D-glucose:NAD oxidoreductase,
  • UDP-glucose:NAD+ oxidoreductase,
  • uridine diphosphate glucose dehydrogenase,
  • UDP-D-glucose dehydrogenase, and
  • uridine diphosphate D-glucose dehydrogenase.

Biochemistry

In enzymology, a UDP-glucose 6-dehydrogenase () is an enzyme that catalyzes the chemical reaction

The 3 substrates of this enzyme are UDP-glucose, oxidised nicotinamide adenine dinucleotide (NAD+), and water. Its products are UDP-glucuronic acid, reduced NADH, and two protons.

References:

References

References

  1. (Sep 1998). "Molecular cloning and characterization of the human and mouse UDP-glucose dehydrogenase genes". The Journal of Biological Chemistry.
  2. (Jan 2000). "Assignment of the UGDH locus encoding UDP-glucose dehydrogenase to human chromosome band 4p15.1 by radiation hybrid mapping". Cytogenetics and Cell Genetics.
  3. "Entrez Gene: UGDH UDP-glucose dehydrogenase".
  4. Hengel, H., Bosso-Lefèvre, C., Grady, G. et al. Loss-of-function mutations in UDP-Glucose 6-Dehydrogenase cause recessive developmental epileptic encephalopathy. Nat Commun 11, 595 (2020). https://doi.org/10.1038/s41467-020-14360-7
  5. {{KEGG enzyme. 1.1.1.22
  6. (Feb 1975). "Uridine diphosphate 2-deoxyglucose. Chemical synthesis, enzymic oxidation and epimerization". Biochimica et Biophysica Acta.
  7. (Aug 1957). "Uridine diphosphoglucose dehydrogenase of pea seedlings". The Biochemical Journal.
  8. (Jan 1957). "Enzymatic formation of uridine diphosphoglucuronic acid". The Journal of Biological Chemistry.
Info: Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

ec-1.1.1 nadh-dependent-enzymes enzymes-of-known-structure
Want to explore this topic further?

Ask Mako anything about UDP-glucose 6-dehydrogenase — get instant answers, deeper analysis, and related topics.

Research with Mako

Free with your Surf account

Content sourced from Wikipedia, available under CC BY-SA 4.0.

This content may have been generated or modified by AI. CloudSurf Software LLC is not responsible for the accuracy, completeness, or reliability of AI-generated content. Always verify important information from primary sources.

Report