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TRNA-dihydrouridine20 synthase (NAD(P)+)

Class of enzymes

Class of enzymes

FieldValue
NameTRNA-dihydrouridine20 synthase (NAD(P)+)
EC_number1.3.1.91

TRNA-dihydrouridine20 synthase (NAD(P)+) (, Dus2p, tRNA-dihydrouridine synthase 2) is an enzyme with systematic name tRNA-5,6-dihydrouracil20:NAD(P)+ oxidoreductase. This enzyme catalyses the following chemical reaction

: 5,6-dihydrouracil20 in tRNA + NAD(P)+ \rightleftharpoons uracil20 in tRNA + NAD(P)H + H+

This enzyme specifically modifies uracil20 in tRNA.

References

References

  1. (April 2004). "The specificities of four yeast dihydrouridine synthases for cytoplasmic tRNAs". The Journal of Biological Chemistry.
  2. (March 2002). "A conserved family of Saccharomyces cerevisiae synthases effects dihydrouridine modification of tRNA". RNA.
  3. (April 2009). "Mechanism of dihydrouridine synthase 2 from yeast and the importance of modifications for efficient tRNA reduction". The Journal of Biological Chemistry.
  4. (July 2005). "A novel human tRNA-dihydrouridine synthase involved in pulmonary carcinogenesis". Cancer Research.
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ec-1.3.1
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