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TRNA-dihydrouridine16/17 synthase (NAD(P)+)

Class of enzymes


Class of enzymes

FieldValue
NameTRNA-dihydrouridine16/17 synthase (NAD(P)+)
EC_number1.3.1.88

TRNA-dihydrouridine16/17 synthase (NAD(P)+) (, Dus1p, tRNA-dihydrouridine synthase 1) is an enzyme with systematic name tRNA-5,6-dihydrouracil16/17:NAD(P)+ oxidoreductase. This enzyme catalyses the following chemical reaction

: (1) 5,6-dihydrouracil16 in tRNA + NAD(P)+ \rightleftharpoons uracil16 in tRNA + NAD(P)H + H+ : (2) 5,6-dihydrouracil17 in tRNA + NAD(P)+ \rightleftharpoons uracil17 in tRNA + NAD(P)H + H+

This enzyme specifically modifies uracil16 and uracil17 in tRNA.

References

References

  1. (April 2004). "The specificities of four yeast dihydrouridine synthases for cytoplasmic tRNAs". The Journal of Biological Chemistry.
  2. (March 2002). "A conserved family of Saccharomyces cerevisiae synthases effects dihydrouridine modification of tRNA". RNA.
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