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Trimethyl phosphate

Methyl phosphate, tribasic Trimethoxyphosphine oxide Trimethyl orthophosphate fraction | NFPA-H = 2 | NFPA-F = 1 | NFPA-R = 0

Trimethyl phosphate is the trimethyl ester of phosphoric acid. It is a colourless, nonvolatile liquid. It has the chemical formula or . It has some specialized uses in the production of other compounds.

Production

Trimethyl phosphate is prepared by treating phosphorus oxychloride with methanol in the presence of an amine base: : It is a tetrahedral molecule that is a weakly polar solvent.

Applications

Trimethyl phosphate is a mild methylating agent, useful for dimethylation of anilines and related heterocyclic compounds.{{OrgSynth

Trimethyl phosphate is used as a solvent for aromatic halogenations and nitrations as required for the preparation of pesticides and pharmaceuticals.

Other applications===

It is used as a color inhibitor for fibers (e.g. polyester) and other polymers. Trimethyl phosphate is used as a simulant for chemical weapon nerve agents.

Safety considerations

With an LD50 of 2g/kg for rats, trimethylphosphate is expected to have low acute toxicity.

References

References

  1. D. E. C. Corbridge "Phosphorus: An Outline of its Chemistry, Biochemistry, and Technology" 5th Edition Elsevier: Amsterdam 1995. {{ISBN. 0-444-89307-5.
  2. J. Svara, N. Weferling, T. Hofmann "Phosphorus Compounds, Organic" in Ullmann's Encyclopedia of Industrial Chemistry, Wiley-VCH, Weinheim, 2006. {{doi. 10.1002/14356007.a19_545.pub2
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organophosphates ester-solvents methyl-esters methylating-agents
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