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TRIM33

Protein-coding gene in the species Homo sapiens

Protein-coding gene in the species Homo sapiens

E3 ubiquitin-protein ligase TRIM33, also known as (ectodermin homolog and tripartite motif-containing 33) is a protein encoded in the human by the gene TRIM33, a member of the tripartite motif family.

TRIM33 is thought to be a transcriptional corepressor. However unlike the related TRIM24 and TRIM28 proteins, few transcription factors such as SMAD4 that interact with TRIM33 have been identified.

Structure

The protein is a member of the tripartite motif family. This motif includes three zinc-binding domains:

  • RING
  • B-box type 1 zinc finger
  • B-box type 2 zinc finger and a coiled-coil region.

Three alternatively spliced transcript variants for this gene have been described, however, the full-length nature of one variant has not been determined.

Interactions

TRIM33 has been shown to interact with TRIM24.

Role in cancer

TRIM33 acts as a tumor suppressor gene preventing the development chronic myelomonocytic leukemia. TRIM33 regulates also the TRIM28 receptor and promotes physiological aging of hematopoietic stem cells. TRIM33 acts as an oncogene by preventing apoptosis in B-cell leukemias.

References

References

  1. "UniProt".
  2. (February 1999). "TIF1gamma, a novel member of the transcriptional intermediary factor 1 family". Oncogene.
  3. "Entrez Gene: TRIM33 tripartite motif-containing 33".
  4. (May 2001). "The tripartite motif family identifies cell compartments". The EMBO Journal.
  5. (July 2002). "Hetero-oligomerization among the TIF family of RBCC/TRIM domain-containing nuclear cofactors: a potential mechanism for regulating the switch between coactivation and corepression". Journal of Molecular Biology.
  6. (June 2011). "Transcription intermediary factor 1γ is a tumor suppressor in mouse and human chronic myelomonocytic leukemia". The Journal of Clinical Investigation.
  7. (July 2014). "Tif1γ regulates the TGF-β1 receptor and promotes physiological aging of hematopoietic stem cells". Proceedings of the National Academy of Sciences of the United States of America.
  8. (April 2015). "The transcriptional cofactor TRIM33 prevents apoptosis in B lymphoblastic leukemia by deactivating a single enhancer". eLife.
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gene-expression transcription-coregulators
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