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Trichlormethiazide

Chemical compound

Trichlormethiazide

Chemical compound

| Drugs.com = Trichlormethiazide (INN, currently being sold under the brand names of Achletin, Diu-Hydrin and Triflumen) is a diuretic with properties similar to those of hydrochlorothiazide. It is usually administered for the treatment of oedema (including that which is associated with heart failure, hepatic cirrhosis and corticosteroid therapy) and hypertension.

As a diuretic (in particular a thiazide), trichlormethiazide encourages water loss from the body. Trichlormethiazide works by inhibiting Na+/Cl− ion reabsorption from the distal tubules of the kidneys. In addition, trichlormethiazide increases the excretion of potassium.

Mechanism

Trichlormethiazide appears to block the active reabsorption of chloride and possibly sodium in the ascending loop of Henle. This results in excretion of sodium, chloride and water, and thus acts as a diuretic. Although trichlormethiazide is used to treat hypertension, its hypotensive effects may not necessarily be due to its role as a diuretic. Thiazides in general cause vasodilation by activating calcium-activated potassium channels in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue.

Synthesis

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References

References

  1. "DrugBank: DB01021 (Trichlormethiazide)". DrugBank.
  2. "Trichlormethiazide and Dexamethasone for veterinary use". Wedgewood Pharmacy.
  3. "Benzthiadiazine derivatives and processes for their manufacture".
  4. "Verfahren zur Herstellung von 2-Alkenyl-7-sulfamyl-3, 4-dihydro-1, 2, 4-benzothiadiazin-1, 1-dioxyden".
  5. (March 1960). "The chemistry and pharmacology of hydrotrichlorothiazide". Experientia.
  6. (May 1960). "3-Haloalkyl-dihydrobenzothiadiazine dioxides as potent diuretic agents.". Experientia.
  7. "Novel process for preparation of dihydrobenzothiadiazines".
  8. {{cite patent
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thiazides diuretics benzothiadiazines sulfonamides organochlorides carbonic-anhydrase-inhibitors dichloromethyl-compounds
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