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Transcriptional noise

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Transcriptional noise is a primary cause of the variability (noise) in gene expression occurring between cells in isogenic populations (see also cellular noise) . A proposed source of transcriptional noise is transcriptional bursting although other sources of heterogeneity, such as unequal separation of cell contents at mitosis are also likely to contribute considerably.{{Cite journal | doi-access = free

Notes

References

  1. (2008). "Nature, nurture, or chance: stochastic gene expression and its consequences". Cell.
  2. (2005). "Real-time kinetics of gene activity in individual bacteria". Cell.
  3. (2006). "Transcriptional pulsing of a developmental gene". Current Biology.
  4. (2006). "Stochastic mRNA synthesis in mammalian cells". PLOS Biology.
  5. (2006). "Phenotypic Consequences of Promoter-Mediated Transcriptional Noise". Molecular Cell.
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