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Thymineless death

Thymineless death is the phenomenon by which bacteria, yeasts and mammalian cells undergo cell death when they are starved of thymidine triphosphate (dTTP), an essential precursor for DNA replication. This phenomenon underlies the mechanism of action of several antibacterial, antimalarial and anticancer agents, such as trimethoprim, sulfamethoxazole, methotrexate and fluorouracil.{{Cite journal

History

The phenomenon was first reported in 1954 by Hazel D. Barner and Seymour S. Cohen in Escherichia coli when thymine-requiring mutants of the bacteria lost viability when grown in a medium lacking thymine but containing other essential nutrients.{{Cite journal | doi-access = free | doi-access = free | doi-access = free | doi-access = free

References

References

  1. Ahmad, S. I.. (October 1998). "Thymine Metabolism and Thymineless Death in Prokaryotes and Eukaryotes". Annual Review of Microbiology.
  2. [http://www.the-scientist.com/news/display/54259/ 50 years ago in cell biology - A virologist recalls his work on cell growth inhibition]
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