Surf Wiki
Save to docs
general/4-methylsulphonyl-phenyl-compounds

From Surf Wiki (app.surf) — the open knowledge base

Thiamphenicol

Antibiotic

Antibiotic

| Drugs.com =

| elimination_half-life = 5.0 hours

Thiamphenicol (also known as thiophenicol and dextrosulphenidol) is an antibiotic. It is the methyl-sulfonyl analogue of chloramphenicol and has a similar spectrum of activity, but is 2.5 to 5 times as potent. Like chloramphenicol, it is insoluble in water, but highly soluble in lipids. It is used in many countries as a veterinary antibiotic, but is available in China, Taiwan, Brazil, Morocco, and Italy for use in humans. Its main advantage over chloramphenicol is that it has never been associated with aplastic anaemia.

Thiamphenicol is also widely used in Brazil, particularly for the treatment of sexually transmitted infections such as pelvic inflammatory disease.

Unlike chloramphenicol, thiamphenicol is not readily metabolized in cattle, poultry, sheep, or humans, but is predominantly excreted unchanged. In pigs and rats the drug is excreted both as parent drug and as thiamphenicol glucuronate.

Thiamphenicol can be administered as a part of a complex molecule, Thiamphenicol glycinate acetylcysteine.

References

References

  1. (2005). "Antimicrobial Agents". American Society for Microbiology.
  2. (2004). "Farmacologia clínica: fundamentos da terapêutica racional". Guanabara Koogan.
  3. (2007). "A therapeutic approach in the treatment of infections of the upper airways: thiamphenicol glycinate acetylcysteinate in sequential treatment (systemic-inhalatory route)". International Journal of Immunopathology and Pharmacology.
Info: Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

4-(methylsulphonyl)phenyl-compounds acetamides amphenicols beta-hydroxyamphetamines diols dichloromethyl-compounds
Want to explore this topic further?

Ask Mako anything about Thiamphenicol — get instant answers, deeper analysis, and related topics.

Research with Mako

Free with your Surf account

Content sourced from Wikipedia, available under CC BY-SA 4.0.

This content may have been generated or modified by AI. CloudSurf Software LLC is not responsible for the accuracy, completeness, or reliability of AI-generated content. Always verify important information from primary sources.

Report