Technetium (99mTc) medronic acid

Chemistry

The drug is a complex of medronic acid (MDP, methylene diphosphonate), the simplest bisphosphonate, with technetium-99m (99mTc), a radionuclide that emits gamma rays. The exact structure of the complex is not known.

Manufacture

99mTc-MDP must be prepared in a radiopharmacy. It is usually supplied as a "cold kit" to which radioactive 99mTc from a generator is added. Kit composition may vary between suppliers, but contents typically includes medronic acid, stannous chloride dihydrate and sometimes ascorbic acid. Pertechnetate, eluted from the generator is added to the kit vial, which is swirled and left to stand. The labelling efficiency, an indication of how much 99mTc remains in pertechnetate form rather than bound to the MDP, can be measured using chromatography.

References

References

1. (April 2005). "Comparison of FDG PET and SPECT for detection of bone metastases in breast cancer". AJR. American Journal of Roentgenology.
2. [https://web.archive.org/web/20100310124217/http://dailymed.nlm.nih.gov/dailymed/getFile.cfm?id=8073&type=pdf&name=19b726a5-c744-46ab-b33d-7e86bbd84b5e FDA Label: MDP Multidose Utilipack]
3. [https://www.genome.jp/dbget-bin/www_bget?dr+D02029 KEGG Drug: D02029]
4. "List of labelling kits for the preparation of a technetium-99m labelled bone scanning agent". IAEA.
5. "MDP Bracco". Bracco Diagnostics.
6. "Kit for the Preparation of Technetium Tc 99m Medronate for Injection". Pharmalucence.
7. "TechneScan MDP Kit for the Preparation of Technetium Tc 99m Medronate Package Insert". Mallinckrodt Medical.
8. (May 1990). "Reduction-mediated technetium-99m labeling of monoclonal antibodies". Journal of Nuclear Medicine.