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Suberosis

Field	Value
name	Suberosis
image	AmCyc Cork - Cork Tree - Cutting Bark.jpg
caption	Cork workers are susceptible to suberosis from breathing in cork dust.
field	Infectious disease, respirology
synonyms	Corkhandler's disease, corkworker's lung

Suberosis is a type of hypersensitivity pneumonitis usually caused by the fungus Penicillium glabrum (formerly called Penicillium frequentans) from exposure to moldy cork dust. Chrysonilia sitophilia, Aspergillus fumigatus, uncontaminated cork dust, and Mucor macedo may also have significant roles in the pathogenesis of the disease.

Cause

Cork is often harvested from the cork oak (Quercus suber) and stored in slabs in a hot and humid environment until covered in mold. Cork workers may be exposed to organic dusts in this process, leading to this disease.

Diagnosis

Chest radiography, high-resolution chest CT, pulmonary function testing, bronchofibroscopy with BAL and transbronchial biopsy, delayed cutaneous hypersensitivity tests, fungal and suberin antigen testing, immediate hypersensitivity specific skin tests, and specific bronchial challenge tests can all be used for diagnosis. Chest radiography can show fine miliary mottling. Obtaining a history of antigen exposure and asking about symptoms (e.g. dyspnea, cough) can also be useful.

Treatment

Avoidance of antigen exposure is beneficial.

History

Vinte-e-Um Mendes first reported respiratory disease in Portuguese cork workers in 1947 at the Portuguese Medical Reunion. Cancella d'Abreu first described the disease in 1955.

References

J-F. Cordier. (December 2011). "European Respiratory Monograph 54: Orphan Lung Diseases". European Respiratory Society.
(2003). "Suberosis: Clinical study and new etiologic agents in a series of eight patients". Chest.
(2003). "Suberosis". Elsevier BV.
Sharma, O.P.. (2012). "Clinical Focus Series:: Hypersensitivity Pneumonitis". Jaypee Brothers Medical Publishers Pvt. Limited.
(1968). "Suberosis Respiratory Disease in Cork Workers". Elsevier BV.

Info: Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

hypersensitivity-pneumonitis

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