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Soluble low-density lipoprotein receptor-related protein

Soluble low-density lipoprotein receptor-related protein (sLRP, LRP-515) is a biological substance naturally produced by the human body. This protein has been found to bind to and neutralize anywhere from 70 to 90 percent of the amyloid-beta peptide that also naturally circulates in healthy human or mouse plasma. Impairment of this function is strongly associated with, and may soon be shown definitively to be the principal cause of, Alzheimer's disease.

References

References

  1. (1999). "Characterization of the soluble form of the low density lipoprotein receptor-related protein (LRP)". Exp. Cell Res..
  2. (1997). "Soluble low density lipoprotein receptor-related protein (LRP) circulates in human plasma". J. Biol. Chem..
  3. "Draining away brain's toxic protein to stop Alzheimer's".
  4. (2007). "Clearance of amyloid-beta by circulating lipoprotein receptors.". Nat. Med..
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