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SKF-97,541

Chemical compound

Chemical compound

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SKF-97,541 is a compound used in scientific research which acts primarily as a selective GABAB receptor agonist. It has sedative effects in animal studies and is widely used in research into potential treatment of various types of drug addiction.

References

References

  1. (December 1990). "Electrophysiological characterization of potent agonists and antagonists at pre- and postsynaptic GABAB receptors on neurones in rat brain slices". British Journal of Pharmacology.
  2. (May 2002). "The GABA(B) antagonist CGP 52432 attenuates the stimulatory effect of the GABA(B) agonist SKF 97541 on luteinizing hormone secretion in the male sheep". Experimental Biology and Medicine.
  3. (July 2004). "GABA(B) receptor agonists reduce operant ethanol self-administration and enhance ethanol sedation in C57BL/6J mice". Psychopharmacology.
  4. (May 2006). "Discriminative stimulus effects of GHB and GABA(B) agonists are differentially attenuated by CGP35348". European Journal of Pharmacology.
  5. (June 2007). "Cataleptic effects of gamma-hydroxybutyrate (GHB), its precursor gamma-butyrolactone (GBL), and GABAB receptor agonists in mice: differential antagonism by the GABAB receptor antagonist CGP35348". Psychopharmacology.
  6. (September 2009). "Behavioral effects of gamma-hydroxybutyrate, its precursor gamma-butyrolactone, and GABA(B) receptor agonists: time course and differential antagonism by the GABA(B) receptor antagonist 3-aminopropyl(diethoxymethyl)phosphinic acid (CGP35348)". The Journal of Pharmacology and Experimental Therapeutics.
  7. (2009). "Effects of GABAB receptor agonists on cocaine hyperlocomotor and sensitizing effects in rats". Pharmacological Reports.
  8. (2020). "Pharmacological targeting of the GABA B receptor alters Drosophila's behavioural responses to alcohol". Addiction Biology.
  9. (September 2020). "The impact of GABAB receptors and their pharmacological stimulation on cocaine reinforcement and drug-seeking behaviors in a rat model of depression". European Journal of Pharmacology.
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serotonin-receptor-agonists gabab-receptor-agonists gabaa-rho-receptor-antagonists organophosphinic-acids
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