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Sign of Hertoghe

Medical sign involving partial eyebrow loss

Field	Value
synonym	Queen Anne's sign
image	Anne of Denmark in mourning.jpg
caption	Anne of Denmark mourning the death of her son Henry in 1612
specialty
causes	Hypothyroidism, atopic dermatitis
named after	Eugene Ludovic Christian Hertoghe

The sign of Hertoghe or Queen Anne's sign is a type of madarosis, more specifically a thinning or loss of the outer third of the eyebrows, and may appear in severe hypothyroidism or atopic dermatitis. It was also observed in lepromatous leprosy, secondary syphilis, hypoparathyroidism, poisoning with either lead or thallium, lupus, or normal aging.

Name

The sign is named after the Belgian internist Eugene Ludovic Christian Hertoghe (April 5, 1860–January 3, 1928), who was a native of Antwerp, and was the first pioneer in thyroid function research. TOC

Queen Anne's sign

The association with Anne of Denmark is based on portraiture, although history does not suggest that she suffered an underactive thyroid. The eponym is disputed by some, though it has been suggested that Anne of France, Anne of Brittany, Anne of Austria, Anne Boleyn, and Anne of Cleves may all be eliminated as candidates.

References

(2021-03-25). "Atopic Dermatitis". New England Journal of Medicine.
(2016-03-29). "Hertoghe sign: an hallmark of lepromatous leprosy". QJM: Monthly Journal of the Association of Physicians.
(Jan–Feb 2008). "Madarosis: A dermatological marker.". Indian Journal of Dermatology, Venereology and Leprology.
(2022-02-14). "Queen Anne sign". Canadian Medical Association Journal.
(2021-01-01). "Eponymous signs in toxicology and poisoning in the nineteenth and early twentieth centuries". Toxicology Reports.
Schatz, Henry A.. (May 1922). "The Role of the Thyroid Gland in Otolaryngology". The Pennsylvania Medical Journal.
(April 1914). "Complimentary Dinner given by Dr. William Seaman Bainbridge". American Medicine.
"Eugène Ludovic Christian Hertoghe (1860-1928) » van Lerberghe genealogy » Genealogy Online".
Lane Furdell E. (May 2007). "Eponymous, anonymous: Queen Anne's sign and the misnaming of a symptom". J Med Biogr.
(2025-04-15). "Removing the Name Queen Anne Sign from the Medical Literature".
Keynes, M. (February 2009). "Letter to the editor". J Med Biogr.

Info: Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

thyroid-disease symptoms-and-signs:-endocrinology,-nutrition,-and-metabolism anne-of-denmark

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