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Setastine

Chemical compound

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Setastine (Loderix) is an antihistamine used to treat allergies and rhinitis.

Pharmacology

Pharmacodynamics

Setastine acts as a highly selective H1 receptor antagonist. It has no anticholinergic, antiadrenergic, or antiserotonergic effects.

Pharmacokinetics

Setastine penetrates the blood-brain-barrier poorly so it is only mildly sedating compared to related molecules like diphenhydramine.

References

(1991). "Loderix (setastine) tablets in the treatment of allergic rhinoconjunctivitis". Therapia Hungarica.
(1989). "Results obtained with Loderix tablet in chronic rhinitis patients". Therapia Hungarica.
(December 1990). "Pharmacology of the new H1-receptor antagonist setastine hydrochloride". Arzneimittel-Forschung.

Info: Wikipedia Source

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h1-receptor-antagonists 4-chlorophenyl-compounds ethers azepanes peripherally-selective-drugs ethanolamines

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