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Sesamol

Note

the component of sesame oil

Benzo[d][1,3]dioxol-5-ol Sesamol 3,4-Methylenedioxyphenol | NFPA-H = 1 | NFPA-F = 1 | NFPA-R = 0 Sesamol is a natural organic compound which is a component of sesame seeds and sesame oil, with anti-inflammatory, antioxidant, antidepressant and neuroprotective properties. It is a white crystalline solid that is a derivative of phenol. It is sparingly soluble in water, but miscible with most oils. It can be produced by organic synthesis from heliotropine.

Sesamol has been found to be an antioxidant that may prevent the spoilage of oils. It also may prevent the spoilage of oils by acting as an antifungal. It can be used in the synthesis of paroxetine.

Sesamol's molecular targets and mechanism of action, at least for its antidepressant-like effects, is found to be through the brain nerve growth factor (NGF) and endocannabinoid signalling under the regulatory drive of the CB1 receptors.

Alexander Shulgin used sesamol in his book PiHKAL to make MMDA-2.

References

References

  1. [http://www.chemicalland21.com/lifescience/phar/3,4-METHYLENEDIOXYPHENOL.htm Sesamol] {{webarchive. link. (2010-01-14 at Chemicalland21.com)
  2. (May 2003). "Antiphoto-oxidative activity of sesamol in methylene blue- and chlorophyll-sensitized photo-oxidation of oil". Journal of Agricultural and Food Chemistry.
  3. (1991). "Sesamol and sesaminol as antioxidants.". New Food Industry.
  4. (June 1997). "Sesamol as an inhibitor of growth and lipid metabolism in Mucor circinelloides via its action on malic enzyme". Lipids.
  5. (2004). "Contemporary drug synthesis". Wiley.
  6. (October 2013). "Implication of NGF and endocannabinoid signaling in the mechanism of action of sesamol: a multi-target natural compound with therapeutic potential". Psychopharmacology.
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natural-phenols phenol-antioxidants benzodioxoles sesame
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