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Semicarbazone
In organic chemistry, a semicarbazone is a derivative of imines formed by a condensation reaction between a ketone or aldehyde and semicarbazide. They are classified as imine derivatives because they are formed from the reaction of an aldehyde or ketone with the terminal -NH2 group of semicarbazide, which behaves very similarly to primary amines.
Formation
;For ketones :H2NNHC(=O)NH2 + RC(=O)R → R2C=NNHC(=O)NH2
;For aldehydes :H2NNHC(=O)NH2 + RCHO → RCH=NNHC(=O)NH2
For example, the semicarbazone of acetone would have the structure (CH3)2C=NNHC(=O)NH2.
Properties and uses
Some semicarbazones, such as nitrofurazone, and thiosemicarbazones are known to have anti-viral and anti-cancer activity, usually mediated through binding to copper or iron in cells. Many semicarbazones are crystalline solids, useful for the identification of the parent aldehydes/ketones by melting point analysis.{{cite book
A thiosemicarbazone is an analog of a semicarbazone which contains a sulfur atom in place of the oxygen atom.
References
This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.
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