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SAE2 (yeast)

SAE2 is a gene in budding yeast, coding for the protein Sae2, which is involved in DNA repair. Sae2 is a part of the homologous recombination process in response to double-strand breaks. It is best characterized in the yeast model organism Saccharomyces cerevisiae. Homologous genes in other organisms include Ctp1 in fission yeast, Com1 in plants, and CtIP in higher eukaryotes including humans.

Sae2 and its homologs have relatively long low-complexity regions in their primary sequences and appear to have large intrinsically unstructured regions. Sae2 likely forms tetramers through coiled-coil sequences. Sae2 has been reported to have endonuclease activity, though it has no bioinformatically recognizable nuclease sequence and reports of this activity are not consistent in the literature.

References

References

  1. (May 2001). "Fidelity of mitotic double-strand-break repair in Saccharomyces cerevisiae: a role for SAE2/COM1.". Genetics.
  2. (August 2017). "CtIP/Ctp1/Sae2, molecular form fit for function". DNA Repair.
  3. (October 2008). "CDK targets Sae2 to control DNA-end resection and homologous recombination". Nature.
  4. (18 November 2005). "The Saccharomyces cerevisiae Sae2 Protein Promotes Resection and Bridging of Double Strand Break Ends". Journal of Biological Chemistry.
  5. (November 2007). "Sae2 Is an Endonuclease that Processes Hairpin DNA Cooperatively with the Mre11/Rad50/Xrs2 Complex". Molecular Cell.
  6. (October 2014). "Sae2 promotes dsDNA endonuclease activity within Mre11–Rad50–Xrs2 to resect DNA breaks". Nature.
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