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general/alpha-alkyltryptamines

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RU-28306

Chemical compound

Chemical compound

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RU-28306, also known as 4,α-methylene-N,N-dimethyltryptamine (4,α-methylene-DMT), is a synthetic indole alkaloid derivative which acts as a serotonin receptor agonist, with selectivity for 5-HT1 and 5-HT2 subtypes. It can be regarded as a conformationally restricted tricyclic derivative of DMT or a structurally simplified derivative of LSD. The binding affinity of racemic RU-28306 is closer to that of DMT than LSD, though with relatively higher affinity for 5-HT2 subtypes and lower for 5-HT1. It has been sold as a designer drug and was first reported to the EMCDDA by a forensic laboratory in Slovenia in 2017. It was subsequently patented by Delix Therapeutics in 2021.

References

References

  1. (October 1987). "Relative selectivity of some conformationally constrained tryptamine analogs at 5-HT1, 5-HT1A and 5-HT2 recognition sites". Life Sciences.
  2. (1991). "Biochemistry and Physiology of Substance Abuse". CRC Press.
  3. [http://www.emcdda.europa.eu/system/files/publications/9282/20183924_TDAN18001ENN_PDF.pdf EMCDDA – Europol 2017 Annual Report on the implementation of Council Decision 2005/387/JHA]
  4. "Ergoline-like compounds for promoting neural plasticity".
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alpha-alkyltryptamines designer-drugs n,n-dialkyltryptamines dimethylamino-compounds heterocyclic-compounds-with-3-rings indoles partial-ergolines phenethylamines psychedelic-drugs serotonin-receptor-agonists
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