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Reversine

Reversine, or 2-(4-morpholinoanilino)-6-cyclohexylaminopurine, is a small molecule developed by the group of Peter G. Schultz, used for stem cell dedifferentiation.

It also has the potential to selectively induce cell death in cancer cells.

Reversine is known to act as an antagonist of the adenosine A3 receptor. Reversine is a potent inhibitor of the mitotic kinase Mps1 and it is widely used to study the process of chromosome segregation.

References

References

  1. (2004). "Dedifferentiation of Lineage-Committed Cells by a Small Molecule". Journal of the American Chemical Society.
  2. (2007). "Reversine increases the plasticity of lineage-committed mammalian cells". Proceedings of the National Academy of Sciences.
  3. (2012). "The synthetic purine reversine selectively induces cell death of cancer cells". Journal of Cellular Biochemistry.
  4. (2010-07-12). "Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversine". The Journal of Cell Biology.
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adenosine-receptor-antagonists purines aromatic-amines 4-morpholinyl-compounds anilines cyclohexyl-compounds
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