Surf Wiki
Save to docs
general/alpha-amino-acids

From Surf Wiki (app.surf) — the open knowledge base

Rebamipide

Amino acid derivative

Amino acid derivative

| Drugs.com =

| elimination_half-life =

Rebamipide, an amino acid derivative of 2-(1H)-quinolinone, is used for mucosal protection, healing of gastroduodenal ulcers, and treatment of gastritis. It works by enhancing mucosal defense, scavenging free radicals, and temporarily activating genes encoding cyclooxygenase-2.

Studies have shown that rebamipide can fight the damaging effects of NSAIDs on the GIT mucosa, and more recently, the small intestine, but not for naproxen-induced gastric damage.

Availability

Rebamipide is used in a number of Asian countries including Japan (marketed as Mucosta), South Korea, China and India (where it is marketed under the trade name Rebagen). It is also approved in Russia under the brand name Rebagit.

Effects

Rebamipide increases gastric mucosal prostaglandin E2, protects gastric mucosa, thereby suppresses gastric mucosal damage and increases gastric mucus secretion and gastric mucosal blood flow, to improve hemodynamic impairment, suppress inflammation and repair the gastric mucosa. It is usually used to treat gastric ulcer and improve gastric mucosal lesion (erosion, bleeding, redness and edema) in acute gastritis and acute exacerbation period of chronic gastritis.

References

  • Rebamipide Tablets 100mg "Kyorin", https://www.rad-ar.or.jp/siori/english/search/result?n=39008

References

  1. (September 1998). "Rebamipide: overview of its mechanisms of action and efficacy in mucosal protection and ulcer healing". Digestive Diseases and Sciences.
  2. (November 1995). "Rebamipide, novel prostaglandin-inducer accelerates healing and reduces relapse of acetic acid-induced rat gastric ulcer. Comparison with cimetidine". Digestive Diseases and Sciences.
  3. (January 2009). "Radical scavengers for elderly patients with age-related hearing loss". Acta Oto-Laryngologica.
  4. (February 2004). "Rebamipide activates genes encoding angiogenic growth factors and Cox2 and stimulates angiogenesis: a key to its ulcer healing action?". Digestive Diseases and Sciences.
  5. (July 2013). "Rebamipide helps defend against nonsteroidal anti-inflammatory drugs induced gastroenteropathy: a systematic review and meta-analysis". Digestive Diseases and Sciences.
  6. (June 2016). "Rebamipide does not protect against naproxen-induced gastric damage: a randomized double-blind controlled trial". BMC Gastroenterology.
  7. "Rebamipide". Drugs.com.
  8. "Registration Sertificate: Rebagit (rebamipide) Film-Coated Tablets". Russian State Register of Medicines..
Info: Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

alpha-amino-acids 2-quinolones benzamides 4-chlorophenyl-compounds
Want to explore this topic further?

Ask Mako anything about Rebamipide — get instant answers, deeper analysis, and related topics.

Research with Mako

Free with your Surf account

Content sourced from Wikipedia, available under CC BY-SA 4.0.

This content may have been generated or modified by AI. CloudSurf Software LLC is not responsible for the accuracy, completeness, or reliability of AI-generated content. Always verify important information from primary sources.

Report