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Quisinostat

Chemical compound

Chemical compound

| Drugs.com = | elimination_half-life =

Quisinostat (USAN; development code JNJ-26481585) is an experimental drug candidate for the treatment of cancer. It is a "second generation" histone deacetylase inhibitor with antineoplastic activity. It is highly potent against class I and II HDACs. TOC

History

It was developed by Janssen Pharmaceuticals and licensed to NewVac LLC.

Preclinical studies show that quisinostat amplifies HDAC-repressed expression of E-cadherin, leading to a reversal of epithelial to mesenchymal transition in tumor cells.

Clinical trials

Results of a phase I trials in patients with multiple myeloma in combination with bortezomib and dexamethasone were published in 2016.

References

References

  1. (2 February 2011). "NCI Drug Dictionary".
  2. "Quisinostat". [[American Medical Association]].
  3. (February 2010). "Preclinical antileukemia activity of JNJ-26481585, a potent second-generation histone deacetylase inhibitor". Leukemia Research.
  4. (May 2010). "Preclinical anti-myeloma activity of the novel HDAC-inhibitor JNJ-26481585". British Journal of Haematology.
  5. "Quisinostat". [[National Cancer Institute]].
  6. (February 2014). "Initial testing (stage 1) of the histone deacetylase inhibitor, quisinostat (JNJ-26481585), by the Pediatric Preclinical Testing Program". Pediatric Blood & Cancer.
  7. LLC, NewVac. "NewVac Reports Primary Endpoint Met in Phase II Clinical Trial of Quisinostat in Combination with Paclitaxel and Carboplatin in Platinum-Resistant Ovarian Cancer".
  8. (July 2016). "Quisinostat, bortezomib, and dexamethasone combination therapy for relapsed multiple myeloma". Leukemia & Lymphoma.
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