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Protoporphyrinogen IX dehydrogenase (menaquinone)

Field	Value
Name	Protoporphyrinogen IX dehydrogenase (menaquinone)
EC_number	1.3.5.3

Protoporphyrinogen IX dehydrogenase (menaquinone) (, HemG) is an enzyme with systematic name protoporphyrinogen IX:menaquinone oxidoreductase. This enzyme catalyses the following chemical reaction

The enzyme uses three equivalents of menaquinone per molecule of protoporphyrinogen IX to provide the oxidant. It enables Escherichia coli to synthesize heme in both aerobic and anaerobic environments.

References

(July 2009). "Identification of Escherichia coli HemG as a novel, menadione-dependent flavodoxin with protoporphyrinogen oxidase activity". Biochemistry.
{{KEGG enzyme. 1.3.5.3
(2010). "Heme biosynthesis is coupled to electron transport chains for energy generation". Proceedings of the National Academy of Sciences.

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ec-1.3.5

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