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Proteinase 3

Mammalian protein found in Homo sapiens

Mammalian protein found in Homo sapiens

Proteinase 3, also known as PRTN3, is an enzyme that in humans is encoded by the PRTN3 gene.

Function

PRTN3 is a serine protease enzyme expressed mainly in neutrophil granulocytes. Its exact role in the function of the neutrophil is unknown, but, in human neutrophils, proteinase 3 contributes to the proteolytic generation of antimicrobial peptides. It is also the target of anti-neutrophil cytoplasmic antibodies (ANCAs) of the c-ANCA (cytoplasmic subtype) class, a type of antibody frequently found in the disease granulomatosis with polyangiitis.

References

References

  1. (December 1990). "Cloning of cDNA for proteinase 3: a serine protease, antibiotic, and autoantigen from human neutrophils". The Journal of Experimental Medicine.
  2. (October 2015). "Proteinase 3-ANCA Vasculitis versus Myeloperoxidase-ANCA Vasculitis". Journal of the American Society of Nephrology.
Info: Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

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