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Propoxur

Propoxur is a carbamate, non-systemic, synthetic insecticide, produced from catechol, and was introduced in 1959 by Bayer.

Action

Carbamate insecticides kill insects by irreversibly inactivating the enzyme acetylcholinesterase, thus it is a Cholinesterase inhibitor.

It has a fast knockdown and long residual effect, and is used against turf, forestry, and household pests and fleas. It is also used in pest control for domestic animals, Anopheles mosquitoes, ants, gypsy moths, and other agricultural pests. It can also be used as a molluscicide.EXTOXNET Extension Toxicology Network. Pesticide Information Profile. Propoxur. June 1996. It has been an ingredient in the consumer insecticide brand, Baygon.

Environmental effects

Propoxur is highly toxic to many bird species, although its toxicity varies by the species, and it is highly toxic to honeybees. It is moderately to slightly toxic to fish and other aquatic species.

EFSA recommends that the active substance should be assessed for neurotoxicity, since propoxur acts by inhibition of acetyl cholinesterase. Several U.S. states have petitioned the Environmental Protection Agency (EPA) to use propoxur against bedbug infestations, but the EPA has been reluctant to approve indoor use because of its potential toxicity to children after chronic exposure.

Propoxur rapidly breaks down in alkaline solution.

Regulation

The use of propoxur products ended in Europe after no manufacturer submitted an application for approval in 2002. Manufacturers reached an agreement with the US EPA to withdraw propoxur from flea and tick collars during 2015-2016 due to concerns about exposure of the ingredient to children.

References

References

  1. {{PGCH. 0531
  2. (2000). "Phenol Derivatives".
  3. (January 2021). "Reasoned opinion on the toxicological properties and maximum residue levels for propoxur". EFSA Journal.
  4. ACGIH, 1991a{{full. (April 2010)
  5. Budavari, 1996a{{full. (April 2010)
  6. Lewis, 1993a{{full. (April 2010)
  7. (September 4, 2010). "In Search of a Bedbug Solution". [[New York Times]].
  8. [http://www.inchem.org/documents/jmpr/jmpmono/v073pr19.htm Propoxur (WHO Pesticide Residues Series 3):] October 01, 2009.
  9. "Companies Agree to Stop Selling Pet Collars Containing Pesticide to Protect Children". US EPA.
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acetylcholinesterase-inhibitors carbamate-insecticides catechol-ethers isopropyl-compounds aromatic-carbamates phenol-esters
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