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Propentofylline

Chemical compound

Chemical compound

| Drugs.com =

| elimination_half-life =

Propentofylline (HWA 285) is a xanthine derivative drug with purported neuroprotective effects.

Pharmacology

It is a phosphodiesterase inhibitor, and also acts as an adenosine reuptake inhibitor.

Uses

Propentofylline was studied as a possible treatment for Alzheimer's disease and multi-infarct dementia, and has been studied, to a lesser extent, as a possible adjunct in the treatment of ischemic stroke, due to its vasodilating properties.

Propentofylline is in use as a veterinary medicine in older dogs.

References

References

  1. (2003). "Propentofylline for dementia". The Cochrane Database of Systematic Reviews.
  2. (April 2008). "A placebo controlled study of the propentofylline added to risperidone in chronic schizophrenia". Progress in Neuro-Psychopharmacology & Biological Psychiatry.
  3. (June 1998). "Effect of propentofylline on free radical generation during cerebral hypoxia in the newborn piglet". Neuroscience.
  4. (September 1997). "Clinical trials in dementia with propentofylline". Annals of the New York Academy of Sciences.
  5. (2004). "Pentoxifylline, propentofylline and pentifylline for acute ischaemic stroke". The Cochrane Database of Systematic Reviews.
  6. (May 1993). "Effect of propentofylline on regional cerebral glucose metabolism in acute ischemic stroke". Journal of Cerebral Blood Flow and Metabolism.
  7. (7 September 2012). "Launch of tablet to make life easier for dogs in old age". Yorkshire Post.
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xanthines alkanones pde4-inhibitors adenosine-reuptake-inhibitors adenosine-receptor-antagonists
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