Proctosedyl

Application

Both the yellowish-white, translucent, greasy ointment and the smooth, off-white suppositories are formulated for the relief of chronic pruritus ani (otherwise known anal itching or anusitis) and the treatment of pain, irritation, discharge and itching associated with haemorrhoids (otherwise known as piles). However both products are also used to provide pain relief in the treatment of anal fissure, for patients undergoing haemorrhoidectomy, (pre and post-operative), in the relief of post-partum (otherwise known as post-natal) haemorrhoidal conditions, and in the treatment of non-infective proctitis.

Active ingredients

Both preparations contain:

• Cinchocaine hydrochloride at a concentration of 5 mg/g to provide anaesthesia, analgesia and to act as a spasmolytic.
• Hydrocortisone at a concentration of 5 mg/g. to provide antipruritic and anti-inflammatory relief

Preparations in some territories may also contain:

• Framycetin sulfate at a concentration of 10 mg/g as an antibacterial agent.
• Aesculin at a concentration of 10 mg/g for its retardant effect on Escherichia coli (otherwise known as E. Coli).

References

References

1. "Patient Information Leaflets Online: Proctosedyl Ointment: PL 04425/0207".
2. "Patient Information Leaflets Online: Proctosedyl Suppositories: PL 04425/0208".
3. "Sanofi Aventis: Hoechst Home Page".
4. "The South African Medical Formulary: C05A Antihaemorrhoidals for topical use".
5. "NetDoctor: Proctosedyl ointment/suppositories".
6. (2004). "Randomized, double-blind trial comparing topical nitroglycerine with xylocaine and Proctosedyl in idiopathic chronic anal fissure". Indian Journal of Gastroenterology.
7. (July 1970). "A general practitioner study to evaluate the efficacy of 'Proctosedyl' ointment in the treatment of acute fissure-in-ano". The British Journal of Clinical Practice.
8. "Medsafe: Information for Health Professionals: Proctosedyl".
9. (1993). "[Our experience in using the preparation Proctosedyl from the Roussel firm in pregnant women with hemorrhoids]". Akusherstvo I Ginekologii͡a.
10. Larsen PO. (September 1992). "[The Danish fund for basic research--a new cigar-box]". Ugeskrift for Laeger.
11. (May 2004). "Effects of esculin and esculetin on the survival of Escherichia coli O157 in human faecal slurries, continuous-flow simulations of the rumen and colon and in calves". The British Journal of Nutrition.