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Pildralazine

Chemical compound

Pildralazine

Chemical compound

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Pildralazine (Atensil), also known as propyldazine or propildazine, is an antihypertensive and vasodilator.

Synthesis

3769278}} (1973 to Isf Spa). </ref>

The reaction between 3,6-Dichloropyridazine [141-30-0] (1) and 1-(Methylamino)-2-propanol [16667-45-1] (2) gives CID:12237595 (3). Reaction with hydrazine completes the synthesis of Pidralazine (4).

References

References

  1. (1997). "Dictionary of pharmacological agents". CRC Press.
  2. (July 1975). "Synthesis and antihypertensive properties of new 3-hydrazinopyridazine derivatives.". Journal of Medicinal Chemistry.
  3. DE2154245 idem G Pifferi, {{US patent. 3769278 (1973 to Isf Spa).
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secondary-alcohols tertiary-amines antihypertensive-agents hydrazines pyridazines
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