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Phenylethylidenehydrazine

Metabolite of an antidepressant drug

Metabolite of an antidepressant drug

| elimination_half-life = ~12 hours

Phenylethylidenehydrazine (PEH), also known as 2-phenylethylhydrazone or β-phenylethylidenehydrazine, is a GABA transaminase inhibitor. It is a metabolite of the antidepressant phenelzine and is responsible for its elevation of GABA concentrations. PEH may contribute to phenelzine's anxiolytic effects.

References

References

  1. (January 2002). "Effects of the antidepressant/antipanic drug phenelzine and its putative metabolite phenylethylidenehydrazine on extracellular gamma-aminobutyric acid levels in the striatum". [[Biochemical Pharmacology (journal).
  2. (2004). "Phenylethylidenehydrazine, a novel GABA-transaminase inhibitor, reduces epileptiform activity in rat hippocampal slices". Neuroscience.
  3. (March 1991). "Effects of the antidepressant phenelzine on brain levels of gamma-aminobutyric acid (GABA)". Journal of Affective Disorders.
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