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Palisaded neutrophilic and granulomatous dermatitis

Connective tissue disease

Field	Value
specialty	Dermatology

Palisaded neutrophilic and granulomatous dermatitis (PNGS) is usually associated with a well-defined connective tissue disease, lupus erythematosus or rheumatoid arthritis most commonly, and often presents with eroded or ulcerated symmetrically distributed umbilicated papules or nodules on the elbows.

Signs and symptoms

Typical clinical manifestations include erythematous to violaceous plaques that are symmetrically distributed, skin-colored linear cords involving the lateral trunks, and skin-colored or erythematous papules with crusting, perforation, or umbilication.

Causes

Palisaded neutrophilic and granulomatous dermaititis is associated with subacute bacterial endocarditis, ledipasvir/sofosbuvir, allopurinol, Hodgkin’s and non-Hodgkin’s lymphoma, chronic myelomonocytic leukemia, ulcerative colitis, Takayasu arteritis, systemic vasculitis, systemic lupus erythematosus (SLE), sarcoidosis, rheumatoid arthritis, eosinophilic granulomatosis with polyangiitis, chronic uveitis, and adult-onset Still’s disease.

Treatment

The underlying illness is the main focus of PNGD treatment. Up to 20% of patients may experience spontaneous resolution of the lesions. Topical corticosteroids, NSAIDs (non-steroidal anti-inflammatory drugs), dapsone, prednisone, colchicine, oral tacrolimus, and TNF inhibitors are among the available treatment options.

References

James, William; Berger, Timothy; Elston, Dirk (2005). ''Andrews' Diseases of the Skin: Clinical Dermatology''. (10th ed.). Saunders. Page 181. {{ISBN. 0-7216-2921-0.
Rapini, Ronald P.. (2007). "Dermatology: 2-Volume Set". Mosby.
(2021). "Palisaded neutrophilic and granulomatous dermatitis following a long-standing monoclonal gammopathy: A case report". SAGE Publications.
(December 11, 2017). "Palisading neutrophilic and granulomatous dermatitis as a presentation of Hodgkin lymphoma: A case and review". Wiley.
(2018). "Palisaded neutrophilic and granulomatous dermatitis associated with ledipasvir/sofosbuvir". Elsevier BV.
(January 18, 2012). "Allopurinol-induced palisaded neutrophilic and granulomatous dermatitis". Informa UK Limited.
(February 20, 2019). "A case of palisaded neutrophilic granulomatous dermatitis with subsequent development of chronic myelomonocytic leukemia". Wiley.
(2015). "Interstitial Granulomatous Dermatitis". Ovid Technologies (Wolters Kluwer Health).
(October 30, 2018). "Palisaded neutrophilic and granulomatous dermatitis associated with systemic lupus erythematosus: possible involvement of CD163⁺ M2 macrophages in two cases, and a review of published works". SAGE Publications.
(2007). "Interstitial Granulomatous Lesions as Part of the Spectrum of Presenting Cutaneous Signs in Pediatric Sarcoidosis". Wiley.
(2002). "Palisaded neutrophilic granulomatous dermatitis in rheumatoid arthritis". Elsevier BV.

Info: Wikipedia Source

This article was imported from Wikipedia and is available under the Creative Commons Attribution-ShareAlike 4.0 License. Content has been adapted to SurfDoc format. Original contributors can be found on the article history page.

connective-tissue-diseases

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