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Octamer transcription factor

Group of proteins

Octamer transcription factors are a family of transcription factors which binds to the "ATTTGCAT" DNA sequence. Their DNA-binding domain is a POU domain.

There are eight Octamer proteins in humans (Oct1–11), which have been renamed according to the different classes of POU domain. Octamer-3/4, also known as POU5F1, is one of the Yamanaka factors, which are critical for the maintenance and self-renewal of embryonic stem cells. On the other hand, Oct-1 and Oct-2 are widely expressed in adult tissues. Oct-7, 8 and 9, also known as "brain factors", are predominantly expressed in the central nervous system during embryonic development. Oct-6 expression is confined to embryonic stem cells and the developing nervous system and skin, while Oct-11 is also involved in skin differentiation.

Human Oct proteins

Oct-1 -
Oct-2 -
Oct-3/4 –
Oct-6 –
Oct-7 –
Oct-8 –
Oct-9 –
Oct-11 –

References

(1990). "Characterization of chicken octamer-binding proteins demonstrates that POU domain-containing homeobox transcription factors have been highly conserved during vertebrate evolution". Proc. Natl. Acad. Sci. U.S.A..
Oct-5 and Oct-10 are not found in humans, while Oct-3 and Oct-4 were identified as the same protein.
(1 June 2013). "Octamer-binding transcription factors: genomics and functions.". Frontiers in Bioscience (Landmark Edition).

Info: Wikipedia Source

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pou-domain-proteins protein-families

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